Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploi...

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Autores principales:	Helen Bolton, Sarah J. L. Graham, Niels Van der Aa, Parveen Kumar, Koen Theunis, Elia Fernandez Gallardo, Thierry Voet, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f312396394384d1dacdd38a6e94d0540
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spelling	oai:doaj.org-article:f312396394384d1dacdd38a6e94d05402021-12-02T16:49:42ZMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential10.1038/ncomms111652041-1723https://doaj.org/article/f312396394384d1dacdd38a6e94d05402016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11165https://doaj.org/toc/2041-1723The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploid cells.Helen BoltonSarah J. L. GrahamNiels Van der AaParveen KumarKoen TheunisElia Fernandez GallardoThierry VoetMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helen Bolton Sarah J. L. Graham Niels Van der Aa Parveen Kumar Koen Theunis Elia Fernandez Gallardo Thierry Voet Magdalena Zernicka-Goetz Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
description	The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploid cells.
format	article
author	Helen Bolton Sarah J. L. Graham Niels Van der Aa Parveen Kumar Koen Theunis Elia Fernandez Gallardo Thierry Voet Magdalena Zernicka-Goetz
author_facet	Helen Bolton Sarah J. L. Graham Niels Van der Aa Parveen Kumar Koen Theunis Elia Fernandez Gallardo Thierry Voet Magdalena Zernicka-Goetz
author_sort	Helen Bolton
title	Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
title_short	Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
title_full	Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
title_fullStr	Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
title_full_unstemmed	Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
title_sort	mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f312396394384d1dacdd38a6e94d0540
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Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

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