Update: Gender differences in CABG outcomes-Have we bridged the gap?

<h4>Background</h4>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivo...

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Autores principales:	Robina Matyal, Nada Qaisar Qureshi, Syed Hamza Mufarrih, Aidan Sharkey, Ruma Bose, Louis M Chu, David C Liu, Venkatachalam Senthilnathan, Feroze Mahmood, Kamal R Khabbaz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f31405b573dc41e3a972b6a6a311ece6
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spelling	oai:doaj.org-article:f31405b573dc41e3a972b6a6a311ece62021-12-02T20:14:36ZUpdate: Gender differences in CABG outcomes-Have we bridged the gap?1932-620310.1371/journal.pone.0255170https://doaj.org/article/f31405b573dc41e3a972b6a6a311ece62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255170https://doaj.org/toc/1932-6203<h4>Background</h4>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG.<h4>Methods</h4>Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors.<h4>Results</h4>Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p<0.001) and hypertensive (89.1% vs. 84.0%, p<0.001). Women had higher adjusted odds of developing ventilator dependence >48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men.<h4>Conclusion</h4>The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.Robina MatyalNada Qaisar QureshiSyed Hamza MufarrihAidan SharkeyRuma BoseLouis M ChuDavid C LiuVenkatachalam SenthilnathanFeroze MahmoodKamal R KhabbazPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255170 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robina Matyal Nada Qaisar Qureshi Syed Hamza Mufarrih Aidan Sharkey Ruma Bose Louis M Chu David C Liu Venkatachalam Senthilnathan Feroze Mahmood Kamal R Khabbaz Update: Gender differences in CABG outcomes-Have we bridged the gap?
description	<h4>Background</h4>Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG.<h4>Methods</h4>Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors.<h4>Results</h4>Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p<0.001) and hypertensive (89.1% vs. 84.0%, p<0.001). Women had higher adjusted odds of developing ventilator dependence >48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men.<h4>Conclusion</h4>The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.
format	article
author	Robina Matyal Nada Qaisar Qureshi Syed Hamza Mufarrih Aidan Sharkey Ruma Bose Louis M Chu David C Liu Venkatachalam Senthilnathan Feroze Mahmood Kamal R Khabbaz
author_facet	Robina Matyal Nada Qaisar Qureshi Syed Hamza Mufarrih Aidan Sharkey Ruma Bose Louis M Chu David C Liu Venkatachalam Senthilnathan Feroze Mahmood Kamal R Khabbaz
author_sort	Robina Matyal
title	Update: Gender differences in CABG outcomes-Have we bridged the gap?
title_short	Update: Gender differences in CABG outcomes-Have we bridged the gap?
title_full	Update: Gender differences in CABG outcomes-Have we bridged the gap?
title_fullStr	Update: Gender differences in CABG outcomes-Have we bridged the gap?
title_full_unstemmed	Update: Gender differences in CABG outcomes-Have we bridged the gap?
title_sort	update: gender differences in cabg outcomes-have we bridged the gap?
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f31405b573dc41e3a972b6a6a311ece6
work_keys_str_mv	AT robinamatyal updategenderdifferencesincabgoutcomeshavewebridgedthegap AT nadaqaisarqureshi updategenderdifferencesincabgoutcomeshavewebridgedthegap AT syedhamzamufarrih updategenderdifferencesincabgoutcomeshavewebridgedthegap AT aidansharkey updategenderdifferencesincabgoutcomeshavewebridgedthegap AT rumabose updategenderdifferencesincabgoutcomeshavewebridgedthegap AT louismchu updategenderdifferencesincabgoutcomeshavewebridgedthegap AT davidcliu updategenderdifferencesincabgoutcomeshavewebridgedthegap AT venkatachalamsenthilnathan updategenderdifferencesincabgoutcomeshavewebridgedthegap AT ferozemahmood updategenderdifferencesincabgoutcomeshavewebridgedthegap AT kamalrkhabbaz updategenderdifferencesincabgoutcomeshavewebridgedthegap
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Update: Gender differences in CABG outcomes-Have we bridged the gap?

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