Profile of serum cytokine concentrations in patients with gouty arthritis

Objective This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). Methods The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendsh...

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Autores principales:	Tie Zhang, Guozhen Wang, Jing Zheng, Shirui Li, Jing Xu
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f317afb5eb9648f984fa9ba23e1551e2
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spelling	oai:doaj.org-article:f317afb5eb9648f984fa9ba23e1551e22021-11-15T00:03:36ZProfile of serum cytokine concentrations in patients with gouty arthritis1473-230010.1177/03000605211055618https://doaj.org/article/f317afb5eb9648f984fa9ba23e1551e22021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211055618https://doaj.org/toc/1473-2300Objective This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). Methods The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendship Hospital from July 2018 to January 2019. Serum cytokine concentrations in patients with GA and volunteers (controls) were determined by a chemiluminescence method. The differences in cytokine concentrations were compared between the two groups. Results Concentrations of serum interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), IL-6, IL-8, and IL-4 were significantly higher in patients with acute GA than in controls. Serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and immunoglobulin E in patients with remission of GA were significantly lower, whereas concentrations of IL-10 and interferon-γ were significantly higher, compared with those in patients with acute GA. Conclusion This study shows that serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and IL-4 are significantly elevated in patients with GA, and may be involved in the pathogenesis of GA.Tie ZhangGuozhen WangJing ZhengShirui LiJing XuSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tie Zhang Guozhen Wang Jing Zheng Shirui Li Jing Xu Profile of serum cytokine concentrations in patients with gouty arthritis
description	Objective This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). Methods The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendship Hospital from July 2018 to January 2019. Serum cytokine concentrations in patients with GA and volunteers (controls) were determined by a chemiluminescence method. The differences in cytokine concentrations were compared between the two groups. Results Concentrations of serum interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), IL-6, IL-8, and IL-4 were significantly higher in patients with acute GA than in controls. Serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and immunoglobulin E in patients with remission of GA were significantly lower, whereas concentrations of IL-10 and interferon-γ were significantly higher, compared with those in patients with acute GA. Conclusion This study shows that serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and IL-4 are significantly elevated in patients with GA, and may be involved in the pathogenesis of GA.
format	article
author	Tie Zhang Guozhen Wang Jing Zheng Shirui Li Jing Xu
author_facet	Tie Zhang Guozhen Wang Jing Zheng Shirui Li Jing Xu
author_sort	Tie Zhang
title	Profile of serum cytokine concentrations in patients with gouty arthritis
title_short	Profile of serum cytokine concentrations in patients with gouty arthritis
title_full	Profile of serum cytokine concentrations in patients with gouty arthritis
title_fullStr	Profile of serum cytokine concentrations in patients with gouty arthritis
title_full_unstemmed	Profile of serum cytokine concentrations in patients with gouty arthritis
title_sort	profile of serum cytokine concentrations in patients with gouty arthritis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/f317afb5eb9648f984fa9ba23e1551e2
work_keys_str_mv	AT tiezhang profileofserumcytokineconcentrationsinpatientswithgoutyarthritis AT guozhenwang profileofserumcytokineconcentrationsinpatientswithgoutyarthritis AT jingzheng profileofserumcytokineconcentrationsinpatientswithgoutyarthritis AT shiruili profileofserumcytokineconcentrationsinpatientswithgoutyarthritis AT jingxu profileofserumcytokineconcentrationsinpatientswithgoutyarthritis
_version_	1718429020438134784

Profile of serum cytokine concentrations in patients with gouty arthritis

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