Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring

Abstract Alterations in the early life environment, including maternal undernutrition (UN) during pregnancy, can lead to increased risk of metabolic and cardiovascular disorders in offspring. Leptin treatment of neonates born to UN rats reverses the programmed metabolic phenotype, but the possible b...

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Autores principales:	Elwyn C. Firth, Greg D. Gamble, Jillian Cornish, Mark H. Vickers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f31aea6f1e2543d092f49a19d5703525
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spelling	oai:doaj.org-article:f31aea6f1e2543d092f49a19d57035252021-12-02T11:40:23ZNeonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring10.1038/s41598-017-07500-52045-2322https://doaj.org/article/f31aea6f1e2543d092f49a19d57035252017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07500-5https://doaj.org/toc/2045-2322Abstract Alterations in the early life environment, including maternal undernutrition (UN) during pregnancy, can lead to increased risk of metabolic and cardiovascular disorders in offspring. Leptin treatment of neonates born to UN rats reverses the programmed metabolic phenotype, but the possible benefits of this treatment on bone tissue have not been defined. We describe for the first time the effects of neonatal leptin treatment on bone in adult offspring following maternal UN. Offspring from either UN or ad libitum-fed (AD) rats were treated with either saline or leptin (2.5 µg/ g.d on postnatal days (D)3–13) and were fed either a chow or high fat (HF) diet from weaning until study completion at D170. Analysis of micro-tomographic data of the left femur showed highly significant effects of UN on cortical and trabecular bone tissue indices, contributing to inferior microstructure and bone strength, almost all of which were reversed by early leptin life treatment. The HF fat diet negatively affected trabecular bone tissue, but the effects of only trabecular separation and number were reversed by leptin treatment. The negative effects of maternal UN on skeletal health in adult offspring might be prevented or attenuated by various interventions including leptin. Establishment of a minimal efficacious leptin dose warrants further study.Elwyn C. FirthGreg D. GambleJillian CornishMark H. VickersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elwyn C. Firth Greg D. Gamble Jillian Cornish Mark H. Vickers Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
description	Abstract Alterations in the early life environment, including maternal undernutrition (UN) during pregnancy, can lead to increased risk of metabolic and cardiovascular disorders in offspring. Leptin treatment of neonates born to UN rats reverses the programmed metabolic phenotype, but the possible benefits of this treatment on bone tissue have not been defined. We describe for the first time the effects of neonatal leptin treatment on bone in adult offspring following maternal UN. Offspring from either UN or ad libitum-fed (AD) rats were treated with either saline or leptin (2.5 µg/ g.d on postnatal days (D)3–13) and were fed either a chow or high fat (HF) diet from weaning until study completion at D170. Analysis of micro-tomographic data of the left femur showed highly significant effects of UN on cortical and trabecular bone tissue indices, contributing to inferior microstructure and bone strength, almost all of which were reversed by early leptin life treatment. The HF fat diet negatively affected trabecular bone tissue, but the effects of only trabecular separation and number were reversed by leptin treatment. The negative effects of maternal UN on skeletal health in adult offspring might be prevented or attenuated by various interventions including leptin. Establishment of a minimal efficacious leptin dose warrants further study.
format	article
author	Elwyn C. Firth Greg D. Gamble Jillian Cornish Mark H. Vickers
author_facet	Elwyn C. Firth Greg D. Gamble Jillian Cornish Mark H. Vickers
author_sort	Elwyn C. Firth
title	Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
title_short	Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
title_full	Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
title_fullStr	Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
title_full_unstemmed	Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
title_sort	neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f31aea6f1e2543d092f49a19d5703525
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Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring

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