Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases

Alginate, the most abundant polysaccharides of brown algae, consists of various proportions of uronic acid epimers <i>α</i>-L-guluronic acid (G) and <i>β</i>-D-mannuronic acid (M). Alginate oligosaccharides (AOs), the degradation products of alginates, exhibit excellent bioac...

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Autores principales:	Shu-Kun Gao, Rui Yin, Xiao-Chen Wang, Hui-Ning Jiang, Xiao-Xiao Liu, Wei Lv, Yu Ma, Yan-Xia Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	alginate lyases structure characteristics biochemical properties pharmaceutical applications Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f31bbf42e47742979525a005c9d1f65a
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spelling	oai:doaj.org-article:f31bbf42e47742979525a005c9d1f65a2021-11-25T18:12:55ZStructure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases10.3390/md191106281660-3397https://doaj.org/article/f31bbf42e47742979525a005c9d1f65a2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/628https://doaj.org/toc/1660-3397Alginate, the most abundant polysaccharides of brown algae, consists of various proportions of uronic acid epimers <i>α</i>-L-guluronic acid (G) and <i>β</i>-D-mannuronic acid (M). Alginate oligosaccharides (AOs), the degradation products of alginates, exhibit excellent bioactivities and a great potential for broad applications in pharmaceutical fields. Alginate lyases can degrade alginate to functional AOs with unsaturated bonds or monosaccharides, which can facilitate the biorefinery of brown algae. On account of the increasing applications of AOs and biorefinery of brown algae, there is a scientific need to explore the important aspects of alginate lyase, such as catalytic mechanism, structure, and property. This review covers fundamental aspects and recent developments in basic information, structural characteristics, the structure–substrate specificity or catalytic efficiency relationship, property, molecular modification, and applications. To meet the needs of biorefinery systems of a broad array of biochemical products, alginate lyases with special properties, such as salt-activated, wide pH adaptation range, and cold adaptation are outlined. Withal, various challenges in alginate lyase research are traced out, and future directions, specifically on the molecular biology part of alginate lyases, are delineated to further widen the horizon of these exceptional alginate lyases.Shu-Kun GaoRui YinXiao-Chen WangHui-Ning JiangXiao-Xiao LiuWei LvYu MaYan-Xia ZhouMDPI AGarticlealginate lyasesstructure characteristicsbiochemical propertiespharmaceutical applicationsBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 628, p 628 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alginate lyases structure characteristics biochemical properties pharmaceutical applications Biology (General) QH301-705.5
spellingShingle	alginate lyases structure characteristics biochemical properties pharmaceutical applications Biology (General) QH301-705.5 Shu-Kun Gao Rui Yin Xiao-Chen Wang Hui-Ning Jiang Xiao-Xiao Liu Wei Lv Yu Ma Yan-Xia Zhou Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
description	Alginate, the most abundant polysaccharides of brown algae, consists of various proportions of uronic acid epimers <i>α</i>-L-guluronic acid (G) and <i>β</i>-D-mannuronic acid (M). Alginate oligosaccharides (AOs), the degradation products of alginates, exhibit excellent bioactivities and a great potential for broad applications in pharmaceutical fields. Alginate lyases can degrade alginate to functional AOs with unsaturated bonds or monosaccharides, which can facilitate the biorefinery of brown algae. On account of the increasing applications of AOs and biorefinery of brown algae, there is a scientific need to explore the important aspects of alginate lyase, such as catalytic mechanism, structure, and property. This review covers fundamental aspects and recent developments in basic information, structural characteristics, the structure–substrate specificity or catalytic efficiency relationship, property, molecular modification, and applications. To meet the needs of biorefinery systems of a broad array of biochemical products, alginate lyases with special properties, such as salt-activated, wide pH adaptation range, and cold adaptation are outlined. Withal, various challenges in alginate lyase research are traced out, and future directions, specifically on the molecular biology part of alginate lyases, are delineated to further widen the horizon of these exceptional alginate lyases.
format	article
author	Shu-Kun Gao Rui Yin Xiao-Chen Wang Hui-Ning Jiang Xiao-Xiao Liu Wei Lv Yu Ma Yan-Xia Zhou
author_facet	Shu-Kun Gao Rui Yin Xiao-Chen Wang Hui-Ning Jiang Xiao-Xiao Liu Wei Lv Yu Ma Yan-Xia Zhou
author_sort	Shu-Kun Gao
title	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
title_short	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
title_full	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
title_fullStr	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
title_full_unstemmed	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases
title_sort	structure characteristics, biochemical properties, and pharmaceutical applications of alginate lyases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f31bbf42e47742979525a005c9d1f65a
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_version_	1718411536269049856

Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases

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