Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of an...

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Autores principales:	Runming Wang, Tsz-Pui Lai, Peng Gao, Hongmin Zhang, Pak-Leung Ho, Patrick Chiu-Yat Woo, Guixing Ma, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f323b829fd714274aab5e5072828f56c
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spelling	oai:doaj.org-article:f323b829fd714274aab5e5072828f56c2021-12-02T15:34:21ZBismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors10.1038/s41467-018-02828-62041-1723https://doaj.org/article/f323b829fd714274aab5e5072828f56c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02828-6https://doaj.org/toc/2041-1723Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.Runming WangTsz-Pui LaiPeng GaoHongmin ZhangPak-Leung HoPatrick Chiu-Yat WooGuixing MaRichard Yi-Tsun KaoHongyan LiHongzhe SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
description	Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.
format	article
author	Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun
author_facet	Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun
author_sort	Runming Wang
title	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_short	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_full	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_fullStr	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_full_unstemmed	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_sort	bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f323b829fd714274aab5e5072828f56c
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Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

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