Making Millennial Medicine More Meta

ABSTRACT Although the importance of human genetic polymorphisms in therapeutic outcomes is well established, the role of specific genotypic or copy number variants in our “second genome” (the microbiome) has been largely overlooked. In this Perspective, I will discuss three major barriers to integra...

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Autor principal:	Peter J. Turnbaugh
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	chemical biology metagenomics microbiome pharmacology precision medicine toxicology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f327593d047b478881c6c38faa387c58
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spelling	oai:doaj.org-article:f327593d047b478881c6c38faa387c582021-12-02T18:15:47ZMaking Millennial Medicine More Meta10.1128/mSystems.00154-172379-5077https://doaj.org/article/f327593d047b478881c6c38faa387c582018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00154-17https://doaj.org/toc/2379-5077ABSTRACT Although the importance of human genetic polymorphisms in therapeutic outcomes is well established, the role of specific genotypic or copy number variants in our “second genome” (the microbiome) has been largely overlooked. In this Perspective, I will discuss three major barriers to integrating metagenomics into pharmacology, highlighting ongoing research by us and others that has begun to shed light on the mechanisms that link the human microbiome to the efficacy and toxicity of small-molecule and biological therapies. The challenges for the next 5 years and beyond are many, requiring interdisciplinary scientific teams working at the interface of chemistry and biology, and a consideration of far more variables than traditionally included in pharmacological modeling. However, the potential benefits are immense. Continued progress could enable more precise tools for predicting patient responses and the development of a new generation of therapeutics based on, or targeted at, the human microbiome.Peter J. TurnbaughAmerican Society for Microbiologyarticlechemical biologymetagenomicsmicrobiomepharmacologyprecision medicinetoxicologyMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemical biology metagenomics microbiome pharmacology precision medicine toxicology Microbiology QR1-502
spellingShingle	chemical biology metagenomics microbiome pharmacology precision medicine toxicology Microbiology QR1-502 Peter J. Turnbaugh Making Millennial Medicine More Meta
description	ABSTRACT Although the importance of human genetic polymorphisms in therapeutic outcomes is well established, the role of specific genotypic or copy number variants in our “second genome” (the microbiome) has been largely overlooked. In this Perspective, I will discuss three major barriers to integrating metagenomics into pharmacology, highlighting ongoing research by us and others that has begun to shed light on the mechanisms that link the human microbiome to the efficacy and toxicity of small-molecule and biological therapies. The challenges for the next 5 years and beyond are many, requiring interdisciplinary scientific teams working at the interface of chemistry and biology, and a consideration of far more variables than traditionally included in pharmacological modeling. However, the potential benefits are immense. Continued progress could enable more precise tools for predicting patient responses and the development of a new generation of therapeutics based on, or targeted at, the human microbiome.
format	article
author	Peter J. Turnbaugh
author_facet	Peter J. Turnbaugh
author_sort	Peter J. Turnbaugh
title	Making Millennial Medicine More Meta
title_short	Making Millennial Medicine More Meta
title_full	Making Millennial Medicine More Meta
title_fullStr	Making Millennial Medicine More Meta
title_full_unstemmed	Making Millennial Medicine More Meta
title_sort	making millennial medicine more meta
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/f327593d047b478881c6c38faa387c58
work_keys_str_mv	AT peterjturnbaugh makingmillennialmedicinemoremeta
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Making Millennial Medicine More Meta

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