Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil

Carbapenem-resistant bacteria are a major cause of diabetic foot (DF) infection. They are resistant to almost all available antimicrobial agents and lead to increased hospital costs. The clinical and microbiological characteristics of DF infection due to these microorganisms and the association of...

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Autores principales:	Stela Braun, Marcia Silva
Formato:	article
Lenguaje:	PT
Publicado:	Universidade do Oeste de Santa Catarina 2021
Materias:	antibiotic bacterial resistance carbapenems diabetic foot Biotechnology TP248.13-248.65 Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/f3276e1450464326a440bd89f661c21f
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spelling	oai:doaj.org-article:f3276e1450464326a440bd89f661c21f2021-11-30T14:18:24ZClinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil10.18593/eba.271781519-52872236-6059https://doaj.org/article/f3276e1450464326a440bd89f661c21f2021-06-01T00:00:00Zhttp://149.28.39.191:8000/index.php/evidencia/article/view/27178https://doaj.org/toc/1519-5287https://doaj.org/toc/2236-6059 Carbapenem-resistant bacteria are a major cause of diabetic foot (DF) infection. They are resistant to almost all available antimicrobial agents and lead to increased hospital costs. The clinical and microbiological characteristics of DF infection due to these microorganisms and the association of DF with outcomes such as mortality and amputation are not yet well established. This was a retrospective cohort study involving 60 vascular surgery patients who were admitted to Nossa Senhora da Conceição Hospital due to DF infection caused by carbapenem-resistant bacteria and who underwent debridement or amputation, and a control group with 60 randomly selected patients. The analyzed parameters were mortality and amputation rates and patients’ epidemiological and microbiological profiles. A significant association was observed between bacterial resistance and previous amputation, previous hospitalizations, and DF ulcer classification into ischemic and neuroischemic; however, there were no differences in mortality and amputation rates between the groups, even after using the Charlson comorbidity index. Although DF infections by carbapenem-resistant bacteria were not statistically associated with worse outcomes, their study is important given that there are few therapeutic options for treating these specific infections. Stela BraunMarcia SilvaUniversidade do Oeste de Santa Catarinaarticleantibiotic bacterial resistancecarbapenemsdiabetic footBiotechnologyTP248.13-248.65Food processing and manufactureTP368-456PTEvidência (2021)
institution	DOAJ
collection	DOAJ
language	PT
topic	antibiotic bacterial resistance carbapenems diabetic foot Biotechnology TP248.13-248.65 Food processing and manufacture TP368-456
spellingShingle	antibiotic bacterial resistance carbapenems diabetic foot Biotechnology TP248.13-248.65 Food processing and manufacture TP368-456 Stela Braun Marcia Silva Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
description	Carbapenem-resistant bacteria are a major cause of diabetic foot (DF) infection. They are resistant to almost all available antimicrobial agents and lead to increased hospital costs. The clinical and microbiological characteristics of DF infection due to these microorganisms and the association of DF with outcomes such as mortality and amputation are not yet well established. This was a retrospective cohort study involving 60 vascular surgery patients who were admitted to Nossa Senhora da Conceição Hospital due to DF infection caused by carbapenem-resistant bacteria and who underwent debridement or amputation, and a control group with 60 randomly selected patients. The analyzed parameters were mortality and amputation rates and patients’ epidemiological and microbiological profiles. A significant association was observed between bacterial resistance and previous amputation, previous hospitalizations, and DF ulcer classification into ischemic and neuroischemic; however, there were no differences in mortality and amputation rates between the groups, even after using the Charlson comorbidity index. Although DF infections by carbapenem-resistant bacteria were not statistically associated with worse outcomes, their study is important given that there are few therapeutic options for treating these specific infections.
format	article
author	Stela Braun Marcia Silva
author_facet	Stela Braun Marcia Silva
author_sort	Stela Braun
title	Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
title_short	Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
title_full	Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
title_fullStr	Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
title_full_unstemmed	Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil
title_sort	clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern brazil
publisher	Universidade do Oeste de Santa Catarina
publishDate	2021
url	https://doaj.org/article/f3276e1450464326a440bd89f661c21f
work_keys_str_mv	AT stelabraun clinicalandmicrobiologicalcharacteristicsofdiabeticfootinfectionbycarbapenemresistantbacteriainahospitalinsouthernbrazil AT marciasilva clinicalandmicrobiologicalcharacteristicsofdiabeticfootinfectionbycarbapenemresistantbacteriainahospitalinsouthernbrazil
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Clinical and microbiological characteristics of diabetic foot infection by carbapenem-resistant bacteria in a hospital in southern Brazil

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