Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis

Abstract Body composition and muscle strength are emerging aspects in idiopathic pulmonary fibrosis (IPF) clinical assessment. We aimed to study the relationships of handgrip strength (HGS) with anthropometric variables, body composition, and disease staging, and to evaluate the prevalence of dynape...

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Autores principales:	Marialuisa Bocchino, Paola Alicante, Ludovica Capitelli, Anna Agnese Stanziola, Lorena Gallotti, Ada Di Gregorio, Gaetano Rea, Alessandro Sanduzzi Zamparelli, Luca Scalfi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f328b1fd36ac4e8886cec817057730c3
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spelling	oai:doaj.org-article:f328b1fd36ac4e8886cec817057730c32021-12-02T19:12:35ZDynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis10.1038/s41598-021-97424-y2045-2322https://doaj.org/article/f328b1fd36ac4e8886cec817057730c32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97424-yhttps://doaj.org/toc/2045-2322Abstract Body composition and muscle strength are emerging aspects in idiopathic pulmonary fibrosis (IPF) clinical assessment. We aimed to study the relationships of handgrip strength (HGS) with anthropometric variables, body composition, and disease staging, and to evaluate the prevalence of dynapenia in 102 clinically stable IPF patients (70 M; mean age: 69.4 years). Fat-free mass (FFM), skeletal muscle (SM) were estimated with bioimpedance analysis. HGS was measured with a digital handle dynamometer for both dominant and non-dominant body sides. Dynapenia was identified according to six recognized criteria sets. Mean body mass index (BMI) was 28.2 ± 4.7 kg/m2, with a prevalence of overweight (BMI > 25 and < 30 kg/m2) and obesity (BMI ≥ 30 kg/m2) of 35% and 37%, respectively. FFM and SM were greater in males, whereas percentage body fat was higher in women. HGS was higher and declined with age slightly more rapidly in men, showing a stronger correlation with FFM and SM. Dynapenia prevalence ranged from 20.6 to 56.9%, depending on the criteria used, and was more frequent in older patients and advanced disease. Dynapenia is highly prevalent in IPF. HGS is a promising proxy marker of muscle function to be used in clinical evaluation and follow-up programs.Marialuisa BocchinoPaola AlicanteLudovica CapitelliAnna Agnese StanziolaLorena GallottiAda Di GregorioGaetano ReaAlessandro Sanduzzi ZamparelliLuca ScalfiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marialuisa Bocchino Paola Alicante Ludovica Capitelli Anna Agnese Stanziola Lorena Gallotti Ada Di Gregorio Gaetano Rea Alessandro Sanduzzi Zamparelli Luca Scalfi Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
description	Abstract Body composition and muscle strength are emerging aspects in idiopathic pulmonary fibrosis (IPF) clinical assessment. We aimed to study the relationships of handgrip strength (HGS) with anthropometric variables, body composition, and disease staging, and to evaluate the prevalence of dynapenia in 102 clinically stable IPF patients (70 M; mean age: 69.4 years). Fat-free mass (FFM), skeletal muscle (SM) were estimated with bioimpedance analysis. HGS was measured with a digital handle dynamometer for both dominant and non-dominant body sides. Dynapenia was identified according to six recognized criteria sets. Mean body mass index (BMI) was 28.2 ± 4.7 kg/m2, with a prevalence of overweight (BMI > 25 and < 30 kg/m2) and obesity (BMI ≥ 30 kg/m2) of 35% and 37%, respectively. FFM and SM were greater in males, whereas percentage body fat was higher in women. HGS was higher and declined with age slightly more rapidly in men, showing a stronger correlation with FFM and SM. Dynapenia prevalence ranged from 20.6 to 56.9%, depending on the criteria used, and was more frequent in older patients and advanced disease. Dynapenia is highly prevalent in IPF. HGS is a promising proxy marker of muscle function to be used in clinical evaluation and follow-up programs.
format	article
author	Marialuisa Bocchino Paola Alicante Ludovica Capitelli Anna Agnese Stanziola Lorena Gallotti Ada Di Gregorio Gaetano Rea Alessandro Sanduzzi Zamparelli Luca Scalfi
author_facet	Marialuisa Bocchino Paola Alicante Ludovica Capitelli Anna Agnese Stanziola Lorena Gallotti Ada Di Gregorio Gaetano Rea Alessandro Sanduzzi Zamparelli Luca Scalfi
author_sort	Marialuisa Bocchino
title	Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
title_short	Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
title_full	Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
title_fullStr	Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
title_full_unstemmed	Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
title_sort	dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f328b1fd36ac4e8886cec817057730c3
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Dynapenia is highly prevalent in older patients with advanced idiopathic pulmonary fibrosis

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