Latent virus reactivation in astronauts on the international space station

Virus reactivation in long-duration spaceflight Long-duration spaceflight increases the reactivation of latent herpes viruses in astronauts and is accompanied by a rise in stress hormone levels. This study shows that the frequency and viral loads of reactivation of Epstein-Barr virus, varicella-zost...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Satish K. Mehta, Mark L. Laudenslager, Raymond P. Stowe, Brian E. Crucian, Alan H. Feiveson, Clarence F. Sams, Duane L. Pierson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/f32947e92776479e9e3b840364e87d36
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f32947e92776479e9e3b840364e87d36
record_format	dspace
spelling	oai:doaj.org-article:f32947e92776479e9e3b840364e87d362021-12-02T11:51:09ZLatent virus reactivation in astronauts on the international space station10.1038/s41526-017-0015-y2373-8065https://doaj.org/article/f32947e92776479e9e3b840364e87d362017-04-01T00:00:00Zhttps://doi.org/10.1038/s41526-017-0015-yhttps://doaj.org/toc/2373-8065Virus reactivation in long-duration spaceflight Long-duration spaceflight increases the reactivation of latent herpes viruses in astronauts and is accompanied by a rise in stress hormone levels. This study shows that the frequency and viral loads of reactivation of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus were even greater in blood, urine, and saliva samples from astronauts staying 60 to 180 days onboard the International Space Station than has previously been observed for short-duration (10–16 days) missions. Changes in viral reactivation were also found to be associated with changes in the daily trajectory of salivary cortisol during these long-duration missions. These results indicate that the effects of the microgravity environment on the immune system are increased with prolonged exposure and highlight the potential increased risk of infection among crewmembers.Satish K. MehtaMark L. LaudenslagerRaymond P. StoweBrian E. CrucianAlan H. FeivesonClarence F. SamsDuane L. PiersonNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Satish K. Mehta Mark L. Laudenslager Raymond P. Stowe Brian E. Crucian Alan H. Feiveson Clarence F. Sams Duane L. Pierson Latent virus reactivation in astronauts on the international space station
description	Virus reactivation in long-duration spaceflight Long-duration spaceflight increases the reactivation of latent herpes viruses in astronauts and is accompanied by a rise in stress hormone levels. This study shows that the frequency and viral loads of reactivation of Epstein-Barr virus, varicella-zoster virus, and cytomegalovirus were even greater in blood, urine, and saliva samples from astronauts staying 60 to 180 days onboard the International Space Station than has previously been observed for short-duration (10–16 days) missions. Changes in viral reactivation were also found to be associated with changes in the daily trajectory of salivary cortisol during these long-duration missions. These results indicate that the effects of the microgravity environment on the immune system are increased with prolonged exposure and highlight the potential increased risk of infection among crewmembers.
format	article
author	Satish K. Mehta Mark L. Laudenslager Raymond P. Stowe Brian E. Crucian Alan H. Feiveson Clarence F. Sams Duane L. Pierson
author_facet	Satish K. Mehta Mark L. Laudenslager Raymond P. Stowe Brian E. Crucian Alan H. Feiveson Clarence F. Sams Duane L. Pierson
author_sort	Satish K. Mehta
title	Latent virus reactivation in astronauts on the international space station
title_short	Latent virus reactivation in astronauts on the international space station
title_full	Latent virus reactivation in astronauts on the international space station
title_fullStr	Latent virus reactivation in astronauts on the international space station
title_full_unstemmed	Latent virus reactivation in astronauts on the international space station
title_sort	latent virus reactivation in astronauts on the international space station
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f32947e92776479e9e3b840364e87d36
work_keys_str_mv	AT satishkmehta latentvirusreactivationinastronautsontheinternationalspacestation AT markllaudenslager latentvirusreactivationinastronautsontheinternationalspacestation AT raymondpstowe latentvirusreactivationinastronautsontheinternationalspacestation AT brianecrucian latentvirusreactivationinastronautsontheinternationalspacestation AT alanhfeiveson latentvirusreactivationinastronautsontheinternationalspacestation AT clarencefsams latentvirusreactivationinastronautsontheinternationalspacestation AT duanelpierson latentvirusreactivationinastronautsontheinternationalspacestation
_version_	1718395200659783680

Latent virus reactivation in astronauts on the international space station

Ejemplares similares