Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatur...
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Nature Portfolio
2021
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oai:doaj.org-article:f32cc8aebe874074a51d470766b32ce02021-12-02T13:35:00ZSingle cell transcriptomic analysis of murine lung development on hyperoxia-induced damage10.1038/s41467-021-21865-22041-1723https://doaj.org/article/f32cc8aebe874074a51d470766b32ce02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21865-2https://doaj.org/toc/2041-1723It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.Maria HurskainenIvana MižíkováDavid P. CookNoora AnderssonChanèle Cyr-DepauwFlore LesageEmmi HelleLaurent RenesmeRobert P. JankovMarkku HeikinheimoBarbara C. VanderhydenBernard ThébaudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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Science Q Maria Hurskainen Ivana Mižíková David P. Cook Noora Andersson Chanèle Cyr-Depauw Flore Lesage Emmi Helle Laurent Renesme Robert P. Jankov Markku Heikinheimo Barbara C. Vanderhyden Bernard Thébaud Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
description |
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia. |
format |
article |
author |
Maria Hurskainen Ivana Mižíková David P. Cook Noora Andersson Chanèle Cyr-Depauw Flore Lesage Emmi Helle Laurent Renesme Robert P. Jankov Markku Heikinheimo Barbara C. Vanderhyden Bernard Thébaud |
author_facet |
Maria Hurskainen Ivana Mižíková David P. Cook Noora Andersson Chanèle Cyr-Depauw Flore Lesage Emmi Helle Laurent Renesme Robert P. Jankov Markku Heikinheimo Barbara C. Vanderhyden Bernard Thébaud |
author_sort |
Maria Hurskainen |
title |
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
title_short |
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
title_full |
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
title_fullStr |
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
title_full_unstemmed |
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
title_sort |
single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0 |
work_keys_str_mv |
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