Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage

It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatur...

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Autores principales: Maria Hurskainen, Ivana Mižíková, David P. Cook, Noora Andersson, Chanèle Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo, Barbara C. Vanderhyden, Bernard Thébaud
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0
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spelling oai:doaj.org-article:f32cc8aebe874074a51d470766b32ce02021-12-02T13:35:00ZSingle cell transcriptomic analysis of murine lung development on hyperoxia-induced damage10.1038/s41467-021-21865-22041-1723https://doaj.org/article/f32cc8aebe874074a51d470766b32ce02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21865-2https://doaj.org/toc/2041-1723It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.Maria HurskainenIvana MižíkováDavid P. CookNoora AnderssonChanèle Cyr-DepauwFlore LesageEmmi HelleLaurent RenesmeRobert P. JankovMarkku HeikinheimoBarbara C. VanderhydenBernard ThébaudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maria Hurskainen
Ivana Mižíková
David P. Cook
Noora Andersson
Chanèle Cyr-Depauw
Flore Lesage
Emmi Helle
Laurent Renesme
Robert P. Jankov
Markku Heikinheimo
Barbara C. Vanderhyden
Bernard Thébaud
Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
description It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.
format article
author Maria Hurskainen
Ivana Mižíková
David P. Cook
Noora Andersson
Chanèle Cyr-Depauw
Flore Lesage
Emmi Helle
Laurent Renesme
Robert P. Jankov
Markku Heikinheimo
Barbara C. Vanderhyden
Bernard Thébaud
author_facet Maria Hurskainen
Ivana Mižíková
David P. Cook
Noora Andersson
Chanèle Cyr-Depauw
Flore Lesage
Emmi Helle
Laurent Renesme
Robert P. Jankov
Markku Heikinheimo
Barbara C. Vanderhyden
Bernard Thébaud
author_sort Maria Hurskainen
title Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
title_short Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
title_full Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
title_fullStr Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
title_full_unstemmed Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
title_sort single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0
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