Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex

The visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Ye...

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Autores principales:	Joana Carvalho, Remco J. Renken, Frans W. Cornelissen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Prediction Masking Population receptive field Connective field Reorganization Artificial scotoma Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f32cfa3219b44782b7bd39d4ba3a0bf3
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spelling	oai:doaj.org-article:f32cfa3219b44782b7bd39d4ba3a0bf32021-11-18T04:44:56ZPredictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex1095-957210.1016/j.neuroimage.2021.118690https://doaj.org/article/f32cfa3219b44782b7bd39d4ba3a0bf32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009630https://doaj.org/toc/1095-9572The visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Yet, it gains particular significance when it masks the perceptual consequences of a retinal lesion, leaving patients unaware of their partial loss of vision and ultimately delaying diagnosis and treatment. At present, our understanding of the neural basis of this masking process is limited which hinders both quantitative modeling as well as translational application. To overcome this, we asked the participants to view visual stimuli with and without superimposed artificial scotoma (AS). We used fMRI to record the associated cortical activity and applied model-based analyzes to track changes in cortical population receptive fields and connectivity in response to the introduction of the AS. We found that throughout the visual field and cortical hierarchy, pRFs shifted their preferred position towards the AS border. Moreover, extrastriate areas biased their sampling of V1 towards sections outside the AS projection zone, thereby effectively masking the AS with signals from spared portions of the visual field. We speculate that the signals that drive these system-wide population modifications originate in extrastriate visual areas and, through feedback, also reconfigure the neural populations in the earlier visual areas.Joana CarvalhoRemco J. RenkenFrans W. CornelissenElsevierarticlePredictionMaskingPopulation receptive fieldConnective fieldReorganizationArtificial scotomaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118690- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prediction Masking Population receptive field Connective field Reorganization Artificial scotoma Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Prediction Masking Population receptive field Connective field Reorganization Artificial scotoma Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Joana Carvalho Remco J. Renken Frans W. Cornelissen Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
description	The visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Yet, it gains particular significance when it masks the perceptual consequences of a retinal lesion, leaving patients unaware of their partial loss of vision and ultimately delaying diagnosis and treatment. At present, our understanding of the neural basis of this masking process is limited which hinders both quantitative modeling as well as translational application. To overcome this, we asked the participants to view visual stimuli with and without superimposed artificial scotoma (AS). We used fMRI to record the associated cortical activity and applied model-based analyzes to track changes in cortical population receptive fields and connectivity in response to the introduction of the AS. We found that throughout the visual field and cortical hierarchy, pRFs shifted their preferred position towards the AS border. Moreover, extrastriate areas biased their sampling of V1 towards sections outside the AS projection zone, thereby effectively masking the AS with signals from spared portions of the visual field. We speculate that the signals that drive these system-wide population modifications originate in extrastriate visual areas and, through feedback, also reconfigure the neural populations in the earlier visual areas.
format	article
author	Joana Carvalho Remco J. Renken Frans W. Cornelissen
author_facet	Joana Carvalho Remco J. Renken Frans W. Cornelissen
author_sort	Joana Carvalho
title	Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
title_short	Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
title_full	Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
title_fullStr	Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
title_full_unstemmed	Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
title_sort	predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f32cfa3219b44782b7bd39d4ba3a0bf3
work_keys_str_mv	AT joanacarvalho predictivemaskingofanartificialscotomaisassociatedwithasystemwidereconfigurationofneuralpopulationsinthehumanvisualcortex AT remcojrenken predictivemaskingofanartificialscotomaisassociatedwithasystemwidereconfigurationofneuralpopulationsinthehumanvisualcortex AT franswcornelissen predictivemaskingofanartificialscotomaisassociatedwithasystemwidereconfigurationofneuralpopulationsinthehumanvisualcortex
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Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex

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