The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Detecting genomic abnormalities in metastatic castration-resistant prostate cancer (mCRPC) may impact clinical treatment. Here, the authors present whole-genome sequencing of metastatic biopsies from 197 mCRPC patients, highlighting the landscape of microsatellite stability, homologous repair defici...

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Autores principales: Lisanne F. van Dessel, Job van Riet, Minke Smits, Yanyun Zhu, Paul Hamberg, Michiel S. van der Heijden, Andries M. Bergman, Inge M. van Oort, Ronald de Wit, Emile E. Voest, Neeltje Steeghs, Takafumi N. Yamaguchi, Julie Livingstone, Paul C. Boutros, John W. M. Martens, Stefan Sleijfer, Edwin Cuppen, Wilbert Zwart, Harmen J. G. van de Werken, Niven Mehra, Martijn P. Lolkema
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f32d1b1a76f44fc6946c2d126cbc501f
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spelling oai:doaj.org-article:f32d1b1a76f44fc6946c2d126cbc501f2021-12-02T16:58:28ZThe genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact10.1038/s41467-019-13084-72041-1723https://doaj.org/article/f32d1b1a76f44fc6946c2d126cbc501f2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13084-7https://doaj.org/toc/2041-1723Detecting genomic abnormalities in metastatic castration-resistant prostate cancer (mCRPC) may impact clinical treatment. Here, the authors present whole-genome sequencing of metastatic biopsies from 197 mCRPC patients, highlighting the landscape of microsatellite stability, homologous repair deficiency, and other genomic subgroups.Lisanne F. van DesselJob van RietMinke SmitsYanyun ZhuPaul HambergMichiel S. van der HeijdenAndries M. BergmanInge M. van OortRonald de WitEmile E. VoestNeeltje SteeghsTakafumi N. YamaguchiJulie LivingstonePaul C. BoutrosJohn W. M. MartensStefan SleijferEdwin CuppenWilbert ZwartHarmen J. G. van de WerkenNiven MehraMartijn P. LolkemaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lisanne F. van Dessel
Job van Riet
Minke Smits
Yanyun Zhu
Paul Hamberg
Michiel S. van der Heijden
Andries M. Bergman
Inge M. van Oort
Ronald de Wit
Emile E. Voest
Neeltje Steeghs
Takafumi N. Yamaguchi
Julie Livingstone
Paul C. Boutros
John W. M. Martens
Stefan Sleijfer
Edwin Cuppen
Wilbert Zwart
Harmen J. G. van de Werken
Niven Mehra
Martijn P. Lolkema
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
description Detecting genomic abnormalities in metastatic castration-resistant prostate cancer (mCRPC) may impact clinical treatment. Here, the authors present whole-genome sequencing of metastatic biopsies from 197 mCRPC patients, highlighting the landscape of microsatellite stability, homologous repair deficiency, and other genomic subgroups.
format article
author Lisanne F. van Dessel
Job van Riet
Minke Smits
Yanyun Zhu
Paul Hamberg
Michiel S. van der Heijden
Andries M. Bergman
Inge M. van Oort
Ronald de Wit
Emile E. Voest
Neeltje Steeghs
Takafumi N. Yamaguchi
Julie Livingstone
Paul C. Boutros
John W. M. Martens
Stefan Sleijfer
Edwin Cuppen
Wilbert Zwart
Harmen J. G. van de Werken
Niven Mehra
Martijn P. Lolkema
author_facet Lisanne F. van Dessel
Job van Riet
Minke Smits
Yanyun Zhu
Paul Hamberg
Michiel S. van der Heijden
Andries M. Bergman
Inge M. van Oort
Ronald de Wit
Emile E. Voest
Neeltje Steeghs
Takafumi N. Yamaguchi
Julie Livingstone
Paul C. Boutros
John W. M. Martens
Stefan Sleijfer
Edwin Cuppen
Wilbert Zwart
Harmen J. G. van de Werken
Niven Mehra
Martijn P. Lolkema
author_sort Lisanne F. van Dessel
title The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
title_short The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
title_full The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
title_fullStr The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
title_full_unstemmed The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
title_sort genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f32d1b1a76f44fc6946c2d126cbc501f
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