Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

Christina Schmitt,1 Anna Lechanteur,2 François Cossais,1 Coralie Bellefroid,2 Philipp Arnold,1 Ralph Lucius,1 Janka Held-Feindt,3 Geraldine Piel,2 Kirsten Hattermann1 1Institute of Anatomy, University Kiel, Kiel D-24098, Germany; 2Laboratory of Pharmaceutical Technology and Biopharmacy (L...

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Autores principales:	Schmitt C, Lechanteur A, Cossais F, Bellefroid C, Arnold P, Lucius R, Held-Feindt J, Piel G, Hattermann K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glial scar neuroinflammation nanoparticles brain implants Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f32f6ce04ff045deb7dc39839e53c9f4
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spelling	oai:doaj.org-article:f32f6ce04ff045deb7dc39839e53c9f42021-12-02T12:35:54ZLiposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices1178-2013https://doaj.org/article/f32f6ce04ff045deb7dc39839e53c9f42020-05-01T00:00:00Zhttps://www.dovepress.com/liposomal-encapsulated-curcumin-effectively-attenuates-neuroinflammato-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Christina Schmitt,1 Anna Lechanteur,2 François Cossais,1 Coralie Bellefroid,2 Philipp Arnold,1 Ralph Lucius,1 Janka Held-Feindt,3 Geraldine Piel,2 Kirsten Hattermann1 1Institute of Anatomy, University Kiel, Kiel D-24098, Germany; 2Laboratory of Pharmaceutical Technology and Biopharmacy (LTPB), CIRM, University of Liège, Liège, Belgium; 3Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, Kiel D-24105, GermanyCorrespondence: Kirsten HattermannInstitute of Anatomy, University Kiel, Olshausenstr. 40, Kiel D-24098, GermanyTel +49 431 880 2460Fax +49 431 880 1557Email k.hattermann@anat.uni-kiel.deIntroduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries.Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis.Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices.Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.Keywords: glial scar, neuroinflammation, nanoparticles, brain implantsSchmitt CLechanteur ACossais FBellefroid CArnold PLucius RHeld-Feindt JPiel GHattermann KDove Medical Pressarticleglial scarneuroinflammationnanoparticlesbrain implantsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3649-3667 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glial scar neuroinflammation nanoparticles brain implants Medicine (General) R5-920
spellingShingle	glial scar neuroinflammation nanoparticles brain implants Medicine (General) R5-920 Schmitt C Lechanteur A Cossais F Bellefroid C Arnold P Lucius R Held-Feindt J Piel G Hattermann K Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
description	Christina Schmitt,1 Anna Lechanteur,2 François Cossais,1 Coralie Bellefroid,2 Philipp Arnold,1 Ralph Lucius,1 Janka Held-Feindt,3 Geraldine Piel,2 Kirsten Hattermann1 1Institute of Anatomy, University Kiel, Kiel D-24098, Germany; 2Laboratory of Pharmaceutical Technology and Biopharmacy (LTPB), CIRM, University of Liège, Liège, Belgium; 3Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, Kiel D-24105, GermanyCorrespondence: Kirsten HattermannInstitute of Anatomy, University Kiel, Olshausenstr. 40, Kiel D-24098, GermanyTel +49 431 880 2460Fax +49 431 880 1557Email k.hattermann@anat.uni-kiel.deIntroduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries.Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis.Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices.Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.Keywords: glial scar, neuroinflammation, nanoparticles, brain implants
format	article
author	Schmitt C Lechanteur A Cossais F Bellefroid C Arnold P Lucius R Held-Feindt J Piel G Hattermann K
author_facet	Schmitt C Lechanteur A Cossais F Bellefroid C Arnold P Lucius R Held-Feindt J Piel G Hattermann K
author_sort	Schmitt C
title	Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_short	Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_full	Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_fullStr	Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_full_unstemmed	Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices
title_sort	liposomal encapsulated curcumin effectively attenuates neuroinflammatory and reactive astrogliosis reactions in glia cells and organotypic brain slices
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f32f6ce04ff045deb7dc39839e53c9f4
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Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

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