Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study

Bezawit Mulat,1 Adugnaw Ambelu,1 Sewbesew Yitayih,2 Yibeltal Yismaw Gela,1 Ayechew Adera,1 Yigizie Yeshaw,1 Yonas Akalu1 1Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Psychiatry, School of Medicine...

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Autores principales:	Mulat B, Ambelu A, Yitayih S, Gela YY, Adera A, Yeshaw Y, Akalu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cognitive impairment hypothyroidism smmse ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f334073ef6d746e087b2f71968bac512
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spelling	oai:doaj.org-article:f334073ef6d746e087b2f71968bac5122021-12-02T17:04:18ZCognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study1178-2021https://doaj.org/article/f334073ef6d746e087b2f71968bac5122021-03-01T00:00:00Zhttps://www.dovepress.com/cognitive-impairment-and-associated-factors-among-adult-hypothyroid-pa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Bezawit Mulat,1 Adugnaw Ambelu,1 Sewbesew Yitayih,2 Yibeltal Yismaw Gela,1 Ayechew Adera,1 Yigizie Yeshaw,1 Yonas Akalu1 1Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Psychiatry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Bezawit Mulat Email mulatbezawit@gmail.comBackground: Cognitive impairment is a common complication of hypothyroidism that affects the patient’s quality of life in different aspects. In Ethiopia, though the prevalence of hypothyroidism is high the magnitude of cognitive impairment among these patients is not known. Therefore, the current study is aimed at determining the prevalence of cognitive impairment and associated factors among adult hypothyroid patients.Methods: An institution-based cross-sectional study was employed from February 24 to May 22, 2020, to assess the prevalence of cognitive impairment and associated factors among adult hypothyroid patients. Data was collected by a pretested interviewer-administered structured questionnaire and standardized Mini-mental state examination (SMMSE) tool. A cluster sampling technique was used. Data was entered into Epidata version 4.6 and exported into a statistical package for social science (SPSS) version 25 for further analysis. Both bivariable and multivariable logistic regression analyses were done. A 95% confidence interval and P-value < 0.05 were used to declare statistical significance.Results: A total of 216 adult hypothyroid patients were included with a response rate of 98.6%. The mean age was 42.5 (± 11) years. The prevalence of cognitive impairment was 27.3% (95% CI (21.7, 33.8)) and it was significantly associated with increased age (AOR = 1.23, 95% CI (1.11, 1.34)), increased duration of illness (AOR = 1.48, 95% CI (1.14, 1.90)) and high thyroid-stimulating hormone (TSH) level (AOR = 1.3, 95% CI (1.1, 1.6)).Conclusion: The prevalence of cognitive impairment among hypothyroid patients was high. Increased age, increased duration of illness and high TSH levels were significantly associated with cognitive impairment. Hence, early screening of cognitive impairment among hypothyroid patients with increased age, increased duration of illness and high TSH level should be given due emphasis to increase patients quality of life.Keywords: cognitive impairment, hypothyroidism, SMMSE, EthiopiaMulat BAmbelu AYitayih SGela YYAdera AYeshaw YAkalu YDove Medical Pressarticlecognitive impairmenthypothyroidismsmmseethiopiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 935-943 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive impairment hypothyroidism smmse ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cognitive impairment hypothyroidism smmse ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mulat B Ambelu A Yitayih S Gela YY Adera A Yeshaw Y Akalu Y Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
description	Bezawit Mulat,1 Adugnaw Ambelu,1 Sewbesew Yitayih,2 Yibeltal Yismaw Gela,1 Ayechew Adera,1 Yigizie Yeshaw,1 Yonas Akalu1 1Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Psychiatry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Bezawit Mulat Email mulatbezawit@gmail.comBackground: Cognitive impairment is a common complication of hypothyroidism that affects the patient’s quality of life in different aspects. In Ethiopia, though the prevalence of hypothyroidism is high the magnitude of cognitive impairment among these patients is not known. Therefore, the current study is aimed at determining the prevalence of cognitive impairment and associated factors among adult hypothyroid patients.Methods: An institution-based cross-sectional study was employed from February 24 to May 22, 2020, to assess the prevalence of cognitive impairment and associated factors among adult hypothyroid patients. Data was collected by a pretested interviewer-administered structured questionnaire and standardized Mini-mental state examination (SMMSE) tool. A cluster sampling technique was used. Data was entered into Epidata version 4.6 and exported into a statistical package for social science (SPSS) version 25 for further analysis. Both bivariable and multivariable logistic regression analyses were done. A 95% confidence interval and P-value < 0.05 were used to declare statistical significance.Results: A total of 216 adult hypothyroid patients were included with a response rate of 98.6%. The mean age was 42.5 (± 11) years. The prevalence of cognitive impairment was 27.3% (95% CI (21.7, 33.8)) and it was significantly associated with increased age (AOR = 1.23, 95% CI (1.11, 1.34)), increased duration of illness (AOR = 1.48, 95% CI (1.14, 1.90)) and high thyroid-stimulating hormone (TSH) level (AOR = 1.3, 95% CI (1.1, 1.6)).Conclusion: The prevalence of cognitive impairment among hypothyroid patients was high. Increased age, increased duration of illness and high TSH levels were significantly associated with cognitive impairment. Hence, early screening of cognitive impairment among hypothyroid patients with increased age, increased duration of illness and high TSH level should be given due emphasis to increase patients quality of life.Keywords: cognitive impairment, hypothyroidism, SMMSE, Ethiopia
format	article
author	Mulat B Ambelu A Yitayih S Gela YY Adera A Yeshaw Y Akalu Y
author_facet	Mulat B Ambelu A Yitayih S Gela YY Adera A Yeshaw Y Akalu Y
author_sort	Mulat B
title	Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
title_short	Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
title_full	Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
title_fullStr	Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
title_full_unstemmed	Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study
title_sort	cognitive impairment and associated factors among adult hypothyroid patients in referral hospitals, amhara region, ethiopia: multicenter cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f334073ef6d746e087b2f71968bac512
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Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study

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