Resveratrol in prevention and treatment of common clinical conditions of aging

M Andrea Markus, Brian J MorrisSchool of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, AustraliaAbstract: Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and veget...

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Autores principales:	M Andrea Markus, Brian J Morris
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	resveratrol longevity SIRT wine ageing cancer Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f335366d0f7c4127a677c971cf338898
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spelling	oai:doaj.org-article:f335366d0f7c4127a677c971cf3388982021-12-02T02:52:39ZResveratrol in prevention and treatment of common clinical conditions of aging1178-1998https://doaj.org/article/f335366d0f7c4127a677c971cf3388982008-06-01T00:00:00Zhttps://www.dovepress.com/resveratrol-in-prevention-and-treatment-of-common-clinical-conditions--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998M Andrea Markus, Brian J MorrisSchool of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, AustraliaAbstract: Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer’s disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.Keywords: resveratrol, longevity, SIRT, wine, aging, cancerM Andrea MarkusBrian J MorrisDove Medical PressarticleresveratrollongevitySIRTwineageingcancerGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 331-339 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	resveratrol longevity SIRT wine ageing cancer Geriatrics RC952-954.6
spellingShingle	resveratrol longevity SIRT wine ageing cancer Geriatrics RC952-954.6 M Andrea Markus Brian J Morris Resveratrol in prevention and treatment of common clinical conditions of aging
description	M Andrea Markus, Brian J MorrisSchool of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, AustraliaAbstract: Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer’s disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.Keywords: resveratrol, longevity, SIRT, wine, aging, cancer
format	article
author	M Andrea Markus Brian J Morris
author_facet	M Andrea Markus Brian J Morris
author_sort	M Andrea Markus
title	Resveratrol in prevention and treatment of common clinical conditions of aging
title_short	Resveratrol in prevention and treatment of common clinical conditions of aging
title_full	Resveratrol in prevention and treatment of common clinical conditions of aging
title_fullStr	Resveratrol in prevention and treatment of common clinical conditions of aging
title_full_unstemmed	Resveratrol in prevention and treatment of common clinical conditions of aging
title_sort	resveratrol in prevention and treatment of common clinical conditions of aging
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/f335366d0f7c4127a677c971cf338898
work_keys_str_mv	AT mandreamarkus resveratrolinpreventionandtreatmentofcommonclinicalconditionsofaging AT brianjmorris resveratrolinpreventionandtreatmentofcommonclinicalconditionsofaging
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Resveratrol in prevention and treatment of common clinical conditions of aging

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