Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis

Abstract Background Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining t...

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Autores principales:	Ayele Semachew Kasa, Tadesse Dagget, Yeshiwork Beyene, Getnet Dessie, Aklilu Endalamaw, Yinager Workineh, Emiru Ayalew, Balew Zeleke, Sitotaw Kerie, Getasew Mulat, Worku Animaw
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cervical cancer Cervical lesion Precancerous Systematic review Ethiopia Medicine R
Acceso en línea:	https://doaj.org/article/f3398e0615ea494db4b06c9c5a9a225d
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spelling	oai:doaj.org-article:f3398e0615ea494db4b06c9c5a9a225d2021-11-07T12:08:08ZPrecancerous cervical lesion in Ethiopia: systematic review and meta-analysis10.1186/s13643-021-01840-02046-4053https://doaj.org/article/f3398e0615ea494db4b06c9c5a9a225d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13643-021-01840-0https://doaj.org/toc/2046-4053Abstract Background Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia. Methods This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I 2 test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented. Result Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16–19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51–23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time. Conclusion Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries.Ayele Semachew KasaTadesse DaggetYeshiwork BeyeneGetnet DessieAklilu EndalamawYinager WorkinehEmiru AyalewBalew ZelekeSitotaw KerieGetasew MulatWorku AnimawBMCarticleCervical cancerCervical lesionPrecancerousSystematic reviewEthiopiaMedicineRENSystematic Reviews, Vol 10, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical cancer Cervical lesion Precancerous Systematic review Ethiopia Medicine R
spellingShingle	Cervical cancer Cervical lesion Precancerous Systematic review Ethiopia Medicine R Ayele Semachew Kasa Tadesse Dagget Yeshiwork Beyene Getnet Dessie Aklilu Endalamaw Yinager Workineh Emiru Ayalew Balew Zeleke Sitotaw Kerie Getasew Mulat Worku Animaw Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
description	Abstract Background Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia. Methods This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I 2 test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented. Result Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16–19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51–23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time. Conclusion Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries.
format	article
author	Ayele Semachew Kasa Tadesse Dagget Yeshiwork Beyene Getnet Dessie Aklilu Endalamaw Yinager Workineh Emiru Ayalew Balew Zeleke Sitotaw Kerie Getasew Mulat Worku Animaw
author_facet	Ayele Semachew Kasa Tadesse Dagget Yeshiwork Beyene Getnet Dessie Aklilu Endalamaw Yinager Workineh Emiru Ayalew Balew Zeleke Sitotaw Kerie Getasew Mulat Worku Animaw
author_sort	Ayele Semachew Kasa
title	Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
title_short	Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
title_full	Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
title_fullStr	Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
title_full_unstemmed	Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis
title_sort	precancerous cervical lesion in ethiopia: systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f3398e0615ea494db4b06c9c5a9a225d
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Precancerous cervical lesion in Ethiopia: systematic review and meta-analysis

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