Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.

Fibromyalgia (FM) is characterized in part by an elevated inflammatory status, and "modified exercise" is currently proposed as being a good therapeutic help for these patients. However, the mechanisms involved in the exercise-induced benefits are still poorly understood. The objective was...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Elena Bote, Juan Jose Garcia, Maria Dolores Hinchado, Eduardo Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f33c20895e134572b1f191b0f53bfbc5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f33c20895e134572b1f191b0f53bfbc5
record_format	dspace
spelling	oai:doaj.org-article:f33c20895e134572b1f191b0f53bfbc52021-11-18T08:56:51ZFibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.1932-620310.1371/journal.pone.0074524https://doaj.org/article/f33c20895e134572b1f191b0f53bfbc52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023948/?tool=EBIhttps://doaj.org/toc/1932-6203Fibromyalgia (FM) is characterized in part by an elevated inflammatory status, and "modified exercise" is currently proposed as being a good therapeutic help for these patients. However, the mechanisms involved in the exercise-induced benefits are still poorly understood. The objective was to evaluate the effect of a single bout of moderate cycling (45 min at 55% VO2 max) on the inflammatory (serum IL-8; chemotaxis and O2 (-) production by neutrophils; and IL-1β, TNF-α, IL-6, IL-10, and IL-18 release by monocytes) and stress (cortisol; NA; and eHsp72) responses in women diagnosed with FM compared with an aged-matched control group of healthy women (HW). IL-8, NA, and eHsp72 were determined by ELISA. Cytokines released by monocytes were determined by Bio-Plex® system (LUMINEX). Cortisol was determined by electrochemoluminiscence, chemotaxis was evaluated in Boyden chambers and O2 (-) production by NBT reduction. In the FM patients, the exercise induced a decrease in the systemic concentration of IL-8, cortisol, NA, and eHsp72; as well as in the neutrophil's chemotaxis and O2 (-) production and in the inflammatory cytokine release by monocytes. This was contrary to the completely expected exercise-induced increase in all those biomarkers in HW. In conclusion, single sessions of moderate cycling can improve the inflammatory status in FM patients, reaching values close to the situation of aged-matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced decrease in the stress response of these patients.Maria Elena BoteJuan Jose GarciaMaria Dolores HinchadoEduardo OrtegaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74524 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Elena Bote Juan Jose Garcia Maria Dolores Hinchado Eduardo Ortega Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
description	Fibromyalgia (FM) is characterized in part by an elevated inflammatory status, and "modified exercise" is currently proposed as being a good therapeutic help for these patients. However, the mechanisms involved in the exercise-induced benefits are still poorly understood. The objective was to evaluate the effect of a single bout of moderate cycling (45 min at 55% VO2 max) on the inflammatory (serum IL-8; chemotaxis and O2 (-) production by neutrophils; and IL-1β, TNF-α, IL-6, IL-10, and IL-18 release by monocytes) and stress (cortisol; NA; and eHsp72) responses in women diagnosed with FM compared with an aged-matched control group of healthy women (HW). IL-8, NA, and eHsp72 were determined by ELISA. Cytokines released by monocytes were determined by Bio-Plex® system (LUMINEX). Cortisol was determined by electrochemoluminiscence, chemotaxis was evaluated in Boyden chambers and O2 (-) production by NBT reduction. In the FM patients, the exercise induced a decrease in the systemic concentration of IL-8, cortisol, NA, and eHsp72; as well as in the neutrophil's chemotaxis and O2 (-) production and in the inflammatory cytokine release by monocytes. This was contrary to the completely expected exercise-induced increase in all those biomarkers in HW. In conclusion, single sessions of moderate cycling can improve the inflammatory status in FM patients, reaching values close to the situation of aged-matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced decrease in the stress response of these patients.
format	article
author	Maria Elena Bote Juan Jose Garcia Maria Dolores Hinchado Eduardo Ortega
author_facet	Maria Elena Bote Juan Jose Garcia Maria Dolores Hinchado Eduardo Ortega
author_sort	Maria Elena Bote
title	Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
title_short	Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
title_full	Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
title_fullStr	Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
title_full_unstemmed	Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
title_sort	fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f33c20895e134572b1f191b0f53bfbc5
work_keys_str_mv	AT mariaelenabote fibromyalgiaantiinflammatoryandstressresponsesafteracutemoderateexercise AT juanjosegarcia fibromyalgiaantiinflammatoryandstressresponsesafteracutemoderateexercise AT mariadoloreshinchado fibromyalgiaantiinflammatoryandstressresponsesafteracutemoderateexercise AT eduardoortega fibromyalgiaantiinflammatoryandstressresponsesafteracutemoderateexercise
_version_	1718421178477969408

Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.

Ejemplares similares