Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation

Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor...

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Autores principales:	A. S. Wahl, U. Büchler, A. Brändli, B. Brattoli, S. Musall, H. Kasper, B. V. Ineichen, F. Helmchen, B. Ommer, M. E. Schwab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f340a87f96194c948b92569a8f2c097d
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spelling	oai:doaj.org-article:f340a87f96194c948b92569a8f2c097d2021-12-02T14:41:18ZOptogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation10.1038/s41467-017-01090-62041-1723https://doaj.org/article/f340a87f96194c948b92569a8f2c097d2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01090-6https://doaj.org/toc/2041-1723Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor functions, rather than compensatory acquisition of new movements.A. S. WahlU. BüchlerA. BrändliB. BrattoliS. MusallH. KasperB. V. IneichenF. HelmchenB. OmmerM. E. SchwabNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. S. Wahl U. Büchler A. Brändli B. Brattoli S. Musall H. Kasper B. V. Ineichen F. Helmchen B. Ommer M. E. Schwab Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
description	Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor functions, rather than compensatory acquisition of new movements.
format	article
author	A. S. Wahl U. Büchler A. Brändli B. Brattoli S. Musall H. Kasper B. V. Ineichen F. Helmchen B. Ommer M. E. Schwab
author_facet	A. S. Wahl U. Büchler A. Brändli B. Brattoli S. Musall H. Kasper B. V. Ineichen F. Helmchen B. Ommer M. E. Schwab
author_sort	A. S. Wahl
title	Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
title_short	Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
title_full	Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
title_fullStr	Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
title_full_unstemmed	Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
title_sort	optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f340a87f96194c948b92569a8f2c097d
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Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation

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