The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.

Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. Th...

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Autores principales:	Thorsten Eierhoff, Eike R Hrincius, Ursula Rescher, Stephan Ludwig, Christina Ehrhardt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f340d3cdb4194ef8a93e14a4fea5ca59
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spelling	oai:doaj.org-article:f340d3cdb4194ef8a93e14a4fea5ca592021-11-18T06:01:38ZThe epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.1553-73661553-737410.1371/journal.ppat.1001099https://doaj.org/article/f340d3cdb4194ef8a93e14a4fea5ca592010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844577/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. This implies engagement of cellular signaling receptors during viral entry. Here, we present first indications for an interplay of IAV with receptor tyrosine kinases (RTKs). As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied. Modulation of expression or activity of both RTKs resulted in altered uptake of IAV, showing that these receptors transmit entry relevant signals upon virus binding. More detailed studies on EGFR function revealed that virus binding lead to clustering of lipid-rafts, suggesting that multivalent binding of IAV to cells induces a signaling platform leading to activation of EGFR and other RTKs that in turn facilitates IAV uptake.Thorsten EierhoffEike R HrinciusUrsula RescherStephan LudwigChristina EhrhardtPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 9, p e1001099 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
description	Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. This implies engagement of cellular signaling receptors during viral entry. Here, we present first indications for an interplay of IAV with receptor tyrosine kinases (RTKs). As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied. Modulation of expression or activity of both RTKs resulted in altered uptake of IAV, showing that these receptors transmit entry relevant signals upon virus binding. More detailed studies on EGFR function revealed that virus binding lead to clustering of lipid-rafts, suggesting that multivalent binding of IAV to cells induces a signaling platform leading to activation of EGFR and other RTKs that in turn facilitates IAV uptake.
format	article
author	Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt
author_facet	Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt
author_sort	Thorsten Eierhoff
title	The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
title_short	The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
title_full	The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
title_fullStr	The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
title_full_unstemmed	The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
title_sort	epidermal growth factor receptor (egfr) promotes uptake of influenza a viruses (iav) into host cells.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f340d3cdb4194ef8a93e14a4fea5ca59
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The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.

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