Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models...
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Nature Portfolio
2018
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oai:doaj.org-article:f343b2e492454377a5d248f3fe9493fb2021-12-02T16:50:10ZNotch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma10.1038/s41467-018-06564-92041-1723https://doaj.org/article/f343b2e492454377a5d248f3fe9493fb2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06564-9https://doaj.org/toc/2041-1723Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models a NOTCH1 blocking antibody decreased spinal metastases.Suzana A. KahnXin WangRyan T. NittaSharareh GholaminJohanna TheruvathGregor HutterTej D. AzadLina WadiSara BolinVijay RamaswamyRogelio EsparzaKun-Wei LiuMichael EdwardsFredrik J. SwartlingDebashis SahooGordon LiRobert J. Wechsler-ReyaJüri ReimandYoon-Jae ChoMichael D. TaylorIrving L. WeissmanSiddhartha S. MitraSamuel H. CheshierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Suzana A. Kahn Xin Wang Ryan T. Nitta Sharareh Gholamin Johanna Theruvath Gregor Hutter Tej D. Azad Lina Wadi Sara Bolin Vijay Ramaswamy Rogelio Esparza Kun-Wei Liu Michael Edwards Fredrik J. Swartling Debashis Sahoo Gordon Li Robert J. Wechsler-Reya Jüri Reimand Yoon-Jae Cho Michael D. Taylor Irving L. Weissman Siddhartha S. Mitra Samuel H. Cheshier Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| description |
Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models a NOTCH1 blocking antibody decreased spinal metastases. |
| format |
article |
| author |
Suzana A. Kahn Xin Wang Ryan T. Nitta Sharareh Gholamin Johanna Theruvath Gregor Hutter Tej D. Azad Lina Wadi Sara Bolin Vijay Ramaswamy Rogelio Esparza Kun-Wei Liu Michael Edwards Fredrik J. Swartling Debashis Sahoo Gordon Li Robert J. Wechsler-Reya Jüri Reimand Yoon-Jae Cho Michael D. Taylor Irving L. Weissman Siddhartha S. Mitra Samuel H. Cheshier |
| author_facet |
Suzana A. Kahn Xin Wang Ryan T. Nitta Sharareh Gholamin Johanna Theruvath Gregor Hutter Tej D. Azad Lina Wadi Sara Bolin Vijay Ramaswamy Rogelio Esparza Kun-Wei Liu Michael Edwards Fredrik J. Swartling Debashis Sahoo Gordon Li Robert J. Wechsler-Reya Jüri Reimand Yoon-Jae Cho Michael D. Taylor Irving L. Weissman Siddhartha S. Mitra Samuel H. Cheshier |
| author_sort |
Suzana A. Kahn |
| title |
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| title_short |
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| title_full |
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| title_fullStr |
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| title_full_unstemmed |
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma |
| title_sort |
notch1 regulates the initiation of metastasis and self-renewal of group 3 medulloblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/f343b2e492454377a5d248f3fe9493fb |
| work_keys_str_mv |
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