Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions?
Introduction: The association patterns of hemoglobin (HB) concentrations with mortality among the longevity older adults are unclear. We aimed to evaluate the relationship among older adults form Chinese longevity regions.Methods: We included 1,785 older adults aged ≥65 years (mean age, 86.7 years;...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f3467e4b3b3f495c83787a04b7aaf5972021-12-01T13:10:16ZIs Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions?2296-256510.3389/fpubh.2021.787935https://doaj.org/article/f3467e4b3b3f495c83787a04b7aaf5972021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.787935/fullhttps://doaj.org/toc/2296-2565Introduction: The association patterns of hemoglobin (HB) concentrations with mortality among the longevity older adults are unclear. We aimed to evaluate the relationship among older adults form Chinese longevity regions.Methods: We included 1,785 older adults aged ≥65 years (mean age, 86.7 years; 1,002 women, 783 men) from the community-based Chinese Longitudinal Healthy Longevity Survey. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality using multivariable Cox proportional hazards models and Cox models with restricted cubic spline.Results: In total, 999 deaths occurred during a median follow-up of 5.4 years from 2011 to 2017. Restricted cubic spline analysis found no non-linear association between HB concentrations and all-cause mortality after a full adjustment for covariates among the older adults form longevity regions (p > 0.05 for non-linearity). The risk for all-cause mortality was significantly higher in the groups with HB concentration of <11.0 g/dL (HR: 1.37, 95% CI: 1.10–1.70) and 11.0–12.0 g/dL (HR: 1.25, 95% CI: 1.01–1.54); the risk of all-cause mortality was significantly lower in the groups with HB concentration ≥14.0 g/dL (HR: 0.76, 95% CI: 0.60–0.97) compared with the reference group (13.0–13.9 g/dL).Conclusions: Among older adults form Chinese longevity regions, HB concentrations were found to be inversely and linearly associated with all-cause mortality. Further prospective intervention trials are needed to confirm whether higher HB concentrations had a lower risk of mortality in these older adults.Jiaojiao RenJiaojiao RenZhenghe WangYujie ZhangPeidong ZhangJianmeng ZhouWenfang ZhongXing WangPingming GaoPingming GaoXiaoming ShiChen MaoFrontiers Media S.A.articlehemoglobin concentrationall-cause mortalityCox models with restricted cubic spline curvesChinese longevity regionsolder adultsPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021) |
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EN |
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hemoglobin concentration all-cause mortality Cox models with restricted cubic spline curves Chinese longevity regions older adults Public aspects of medicine RA1-1270 |
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hemoglobin concentration all-cause mortality Cox models with restricted cubic spline curves Chinese longevity regions older adults Public aspects of medicine RA1-1270 Jiaojiao Ren Jiaojiao Ren Zhenghe Wang Yujie Zhang Peidong Zhang Jianmeng Zhou Wenfang Zhong Xing Wang Pingming Gao Pingming Gao Xiaoming Shi Chen Mao Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| description |
Introduction: The association patterns of hemoglobin (HB) concentrations with mortality among the longevity older adults are unclear. We aimed to evaluate the relationship among older adults form Chinese longevity regions.Methods: We included 1,785 older adults aged ≥65 years (mean age, 86.7 years; 1,002 women, 783 men) from the community-based Chinese Longitudinal Healthy Longevity Survey. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality using multivariable Cox proportional hazards models and Cox models with restricted cubic spline.Results: In total, 999 deaths occurred during a median follow-up of 5.4 years from 2011 to 2017. Restricted cubic spline analysis found no non-linear association between HB concentrations and all-cause mortality after a full adjustment for covariates among the older adults form longevity regions (p > 0.05 for non-linearity). The risk for all-cause mortality was significantly higher in the groups with HB concentration of <11.0 g/dL (HR: 1.37, 95% CI: 1.10–1.70) and 11.0–12.0 g/dL (HR: 1.25, 95% CI: 1.01–1.54); the risk of all-cause mortality was significantly lower in the groups with HB concentration ≥14.0 g/dL (HR: 0.76, 95% CI: 0.60–0.97) compared with the reference group (13.0–13.9 g/dL).Conclusions: Among older adults form Chinese longevity regions, HB concentrations were found to be inversely and linearly associated with all-cause mortality. Further prospective intervention trials are needed to confirm whether higher HB concentrations had a lower risk of mortality in these older adults. |
| format |
article |
| author |
Jiaojiao Ren Jiaojiao Ren Zhenghe Wang Yujie Zhang Peidong Zhang Jianmeng Zhou Wenfang Zhong Xing Wang Pingming Gao Pingming Gao Xiaoming Shi Chen Mao |
| author_facet |
Jiaojiao Ren Jiaojiao Ren Zhenghe Wang Yujie Zhang Peidong Zhang Jianmeng Zhou Wenfang Zhong Xing Wang Pingming Gao Pingming Gao Xiaoming Shi Chen Mao |
| author_sort |
Jiaojiao Ren |
| title |
Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| title_short |
Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| title_full |
Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| title_fullStr |
Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| title_full_unstemmed |
Is Hemoglobin Concentration a Linear Predictor of Mortality in Older Adults From Chinese Longevity Regions? |
| title_sort |
is hemoglobin concentration a linear predictor of mortality in older adults from chinese longevity regions? |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f3467e4b3b3f495c83787a04b7aaf597 |
| work_keys_str_mv |
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