Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study

Abstract Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from consecutive advanced Parkinson’s disease patients treated in routine care were retrospectively collected over...

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Autores principales:	Bruna Meira, Bertrand Degos, Elise Corsetti, Mohamed Doulazmi, Emeline Berthelot, Clara Virbel-Fleischman, Pauline Dodet, Aurélie Méneret, Louise-Laure Mariani, Cécile Delorme, Florence Cormier-Dequaire, David Bendetowicz, Nicolas Villain, Clément Tarrano, Lise Mantisi, Hélène Letrillart, Céline Louapre, Eavan McGovern, Yulia Worbe, David Grabli, Marie Vidailhet, Elodie Hainque, Emmanuel Roze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f346fe136aee4bfcb71a0c5f818bfacc
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spelling	oai:doaj.org-article:f346fe136aee4bfcb71a0c5f818bfacc2021-12-02T17:51:42ZLong-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study10.1038/s41531-021-00194-72373-8057https://doaj.org/article/f346fe136aee4bfcb71a0c5f818bfacc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00194-7https://doaj.org/toc/2373-8057Abstract Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from consecutive advanced Parkinson’s disease patients treated in routine care were retrospectively collected over 24 months after CSAI initiation, with a focus on the 39-item Parkinson’s disease questionnaire (PDQ-39). We determined predictors of CSAI discontinuation and HRQoL improvement using multiple regression analysis. Of the 110 subjects evaluated over a 2-year period, 35% discontinued CSAI. Of those who continued treatment, HRQoL remained stable with a sustained reduction in motor fluctuations. The observed effect on dyskinesias was mild and transient. Of note, patients with preexisting impulse control disorders showed an overall good tolerability. PDQ-39 was the only baseline predictor of HRQoL improvement after 2 years of treatment. The presence of dyskinesias, poorer psychological status, shorter disease duration, male sex, and worse OFF state were predictors of discontinuation. Best candidates for CSAI are patients with: (i) poor baseline HRQoL and (ii) marked motor fluctuations.Bruna MeiraBertrand DegosElise CorsettiMohamed DoulazmiEmeline BerthelotClara Virbel-FleischmanPauline DodetAurélie MéneretLouise-Laure MarianiCécile DelormeFlorence Cormier-DequaireDavid BendetowiczNicolas VillainClément TarranoLise MantisiHélène LetrillartCéline LouapreEavan McGovernYulia WorbeDavid GrabliMarie VidailhetElodie HainqueEmmanuel RozeNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Bruna Meira Bertrand Degos Elise Corsetti Mohamed Doulazmi Emeline Berthelot Clara Virbel-Fleischman Pauline Dodet Aurélie Méneret Louise-Laure Mariani Cécile Delorme Florence Cormier-Dequaire David Bendetowicz Nicolas Villain Clément Tarrano Lise Mantisi Hélène Letrillart Céline Louapre Eavan McGovern Yulia Worbe David Grabli Marie Vidailhet Elodie Hainque Emmanuel Roze Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
description	Abstract Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from consecutive advanced Parkinson’s disease patients treated in routine care were retrospectively collected over 24 months after CSAI initiation, with a focus on the 39-item Parkinson’s disease questionnaire (PDQ-39). We determined predictors of CSAI discontinuation and HRQoL improvement using multiple regression analysis. Of the 110 subjects evaluated over a 2-year period, 35% discontinued CSAI. Of those who continued treatment, HRQoL remained stable with a sustained reduction in motor fluctuations. The observed effect on dyskinesias was mild and transient. Of note, patients with preexisting impulse control disorders showed an overall good tolerability. PDQ-39 was the only baseline predictor of HRQoL improvement after 2 years of treatment. The presence of dyskinesias, poorer psychological status, shorter disease duration, male sex, and worse OFF state were predictors of discontinuation. Best candidates for CSAI are patients with: (i) poor baseline HRQoL and (ii) marked motor fluctuations.
format	article
author	Bruna Meira Bertrand Degos Elise Corsetti Mohamed Doulazmi Emeline Berthelot Clara Virbel-Fleischman Pauline Dodet Aurélie Méneret Louise-Laure Mariani Cécile Delorme Florence Cormier-Dequaire David Bendetowicz Nicolas Villain Clément Tarrano Lise Mantisi Hélène Letrillart Céline Louapre Eavan McGovern Yulia Worbe David Grabli Marie Vidailhet Elodie Hainque Emmanuel Roze
author_facet	Bruna Meira Bertrand Degos Elise Corsetti Mohamed Doulazmi Emeline Berthelot Clara Virbel-Fleischman Pauline Dodet Aurélie Méneret Louise-Laure Mariani Cécile Delorme Florence Cormier-Dequaire David Bendetowicz Nicolas Villain Clément Tarrano Lise Mantisi Hélène Letrillart Céline Louapre Eavan McGovern Yulia Worbe David Grabli Marie Vidailhet Elodie Hainque Emmanuel Roze
author_sort	Bruna Meira
title	Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
title_short	Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
title_full	Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
title_fullStr	Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
title_full_unstemmed	Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study
title_sort	long-term effect of apomorphine infusion in advanced parkinson’s disease: a real-life study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f346fe136aee4bfcb71a0c5f818bfacc
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Long-term effect of apomorphine infusion in advanced Parkinson’s disease: a real-life study

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