The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh

Atopic dermatitis (AD) is the foremost non-fatal skin-related disease that affects all age groups. Despite the growing prevalence of AD in low- and middle-income countries, its physiological consequences remain overlooked in countries like Bangladesh. Therefore, we aim to assess and characterize the...

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Autores principales:	Abir Nagata, Taheruzzaman Kazi, Zubaida Akter, Fariha Afrin Nody, Mohammad Shahriar Khan, Abu Saleh Muhammad Shahriar, Md Sayeedul Islam, Takatoshi Nakagawa, Shigeki Inui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atopic dermatitis disease severity Dermatology Life Quality Index Eczema Area and Severity Index health-related quality of life Medicine R
Acceso en línea:	https://doaj.org/article/f3487a8ab0254a1c9d00eaae99d0b801
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spelling	oai:doaj.org-article:f3487a8ab0254a1c9d00eaae99d0b8012021-11-11T16:41:57ZThe Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh10.3390/ijerph1821115931660-46011661-7827https://doaj.org/article/f3487a8ab0254a1c9d00eaae99d0b8012021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11593https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Atopic dermatitis (AD) is the foremost non-fatal skin-related disease that affects all age groups. Despite the growing prevalence of AD in low- and middle-income countries, its physiological consequences remain overlooked in countries like Bangladesh. Therefore, we aim to assess and characterize the influence of AD on the health-related quality of life (HRQoL) in Bangladeshi patients. A cross-sectional study comprising 184 eligible adults (83 men and 101 women; mean age, 33.46 ± 15.44 years) was conducted at the dermatology outpatient department of Shaheed Suhrawardy Medical College Hospital (a tertiary hospital in Dhaka, Bangladesh). AD was determined using the UK Working Party criteria. A structured questionnaire, Eczema Area and Severity Index (EASI), and Dermatology Life Quality Index (DLQI) were administered to obtain information on patient characteristics, AD severity, and HRQoL. The mean DLQI score for the entire sample was 11.29 ± 5.27 (range, 1–26), and 51.60% reported the disease greatly affected their lives. Bivariate analysis revealed significant differences in self-rated health measures of DLQI scores in terms of self-reported AD severity, overall health, and the EASI. In multivariable regression models adjusted for patient characteristics, the self-perceived severe AD group reported significantly higher DLQI scores (coefficient = 2.72; 95% confidence interval (CI) = 0.38–5.05; <i>p</i> = 0.022) than the mild group. Concurrently, we observed a substantial increase in the DLQI scores among patients with moderate and severe EASI scores (coefficient = 1.96, 95% CI = 0.08–3.92, <i>p</i> < 0.05 and coefficient = 4.35, 95% CI = 1.98–6.72, <i>p</i> < 0.001, respectively) than in those with mild EASI scores, suggesting that HRQoL was markedly influenced by greater AD severity. These findings highlight the need for a more patient-centric approach to the management of AD in order to alleviate patient suffering and, thereby, improve HRQoL.Abir NagataTaheruzzaman KaziZubaida AkterFariha Afrin NodyMohammad Shahriar KhanAbu Saleh Muhammad ShahriarMd Sayeedul IslamTakatoshi NakagawaShigeki InuiMDPI AGarticleatopic dermatitisdisease severityDermatology Life Quality IndexEczema Area and Severity Indexhealth-related quality of lifeMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11593, p 11593 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis disease severity Dermatology Life Quality Index Eczema Area and Severity Index health-related quality of life Medicine R
spellingShingle	atopic dermatitis disease severity Dermatology Life Quality Index Eczema Area and Severity Index health-related quality of life Medicine R Abir Nagata Taheruzzaman Kazi Zubaida Akter Fariha Afrin Nody Mohammad Shahriar Khan Abu Saleh Muhammad Shahriar Md Sayeedul Islam Takatoshi Nakagawa Shigeki Inui The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
description	Atopic dermatitis (AD) is the foremost non-fatal skin-related disease that affects all age groups. Despite the growing prevalence of AD in low- and middle-income countries, its physiological consequences remain overlooked in countries like Bangladesh. Therefore, we aim to assess and characterize the influence of AD on the health-related quality of life (HRQoL) in Bangladeshi patients. A cross-sectional study comprising 184 eligible adults (83 men and 101 women; mean age, 33.46 ± 15.44 years) was conducted at the dermatology outpatient department of Shaheed Suhrawardy Medical College Hospital (a tertiary hospital in Dhaka, Bangladesh). AD was determined using the UK Working Party criteria. A structured questionnaire, Eczema Area and Severity Index (EASI), and Dermatology Life Quality Index (DLQI) were administered to obtain information on patient characteristics, AD severity, and HRQoL. The mean DLQI score for the entire sample was 11.29 ± 5.27 (range, 1–26), and 51.60% reported the disease greatly affected their lives. Bivariate analysis revealed significant differences in self-rated health measures of DLQI scores in terms of self-reported AD severity, overall health, and the EASI. In multivariable regression models adjusted for patient characteristics, the self-perceived severe AD group reported significantly higher DLQI scores (coefficient = 2.72; 95% confidence interval (CI) = 0.38–5.05; <i>p</i> = 0.022) than the mild group. Concurrently, we observed a substantial increase in the DLQI scores among patients with moderate and severe EASI scores (coefficient = 1.96, 95% CI = 0.08–3.92, <i>p</i> < 0.05 and coefficient = 4.35, 95% CI = 1.98–6.72, <i>p</i> < 0.001, respectively) than in those with mild EASI scores, suggesting that HRQoL was markedly influenced by greater AD severity. These findings highlight the need for a more patient-centric approach to the management of AD in order to alleviate patient suffering and, thereby, improve HRQoL.
format	article
author	Abir Nagata Taheruzzaman Kazi Zubaida Akter Fariha Afrin Nody Mohammad Shahriar Khan Abu Saleh Muhammad Shahriar Md Sayeedul Islam Takatoshi Nakagawa Shigeki Inui
author_facet	Abir Nagata Taheruzzaman Kazi Zubaida Akter Fariha Afrin Nody Mohammad Shahriar Khan Abu Saleh Muhammad Shahriar Md Sayeedul Islam Takatoshi Nakagawa Shigeki Inui
author_sort	Abir Nagata
title	The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
title_short	The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
title_full	The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
title_fullStr	The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
title_full_unstemmed	The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh
title_sort	influence of atopic dermatitis on health-related quality of life in bangladesh
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f3487a8ab0254a1c9d00eaae99d0b801
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The Influence of Atopic Dermatitis on Health-Related Quality of Life in Bangladesh

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