p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, ind...

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Autores principales:	Robert A.H. van de Ven, Jolien S. de Groot, Danielle Park, Robert van Domselaar, Danielle de Jong, Karoly Szuhai, Elsken van der Wall, Oscar M. Rueda, H. Raza Ali, Carlos Caldas, Paul J. van Diest, Martin W. Hetzer, Erik Sahai, Patrick W.B. Derksen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c
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spelling	oai:doaj.org-article:f34cb9a535fd4607bed79e5018991e0c2021-12-02T14:40:16Zp120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis10.1038/ncomms138742041-1723https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13874https://doaj.org/toc/2041-1723The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, independent of cell-cell adhesion.Robert A.H. van de VenJolien S. de GrootDanielle ParkRobert van DomselaarDanielle de JongKaroly SzuhaiElsken van der WallOscar M. RuedaH. Raza AliCarlos CaldasPaul J. van DiestMartin W. HetzerErik SahaiPatrick W.B. DerksenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert A.H. van de Ven Jolien S. de Groot Danielle Park Robert van Domselaar Danielle de Jong Karoly Szuhai Elsken van der Wall Oscar M. Rueda H. Raza Ali Carlos Caldas Paul J. van Diest Martin W. Hetzer Erik Sahai Patrick W.B. Derksen p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
description	The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, independent of cell-cell adhesion.
format	article
author	Robert A.H. van de Ven Jolien S. de Groot Danielle Park Robert van Domselaar Danielle de Jong Karoly Szuhai Elsken van der Wall Oscar M. Rueda H. Raza Ali Carlos Caldas Paul J. van Diest Martin W. Hetzer Erik Sahai Patrick W.B. Derksen
author_facet	Robert A.H. van de Ven Jolien S. de Groot Danielle Park Robert van Domselaar Danielle de Jong Karoly Szuhai Elsken van der Wall Oscar M. Rueda H. Raza Ali Carlos Caldas Paul J. van Diest Martin W. Hetzer Erik Sahai Patrick W.B. Derksen
author_sort	Robert A.H. van de Ven
title	p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
title_short	p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
title_full	p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
title_fullStr	p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
title_full_unstemmed	p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
title_sort	p120-catenin prevents multinucleation through control of mklp1-dependent rhoa activity during cytokinesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c
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p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

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