p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, ind...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|