HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization of the PA-producing enzyme phospholipase D1.

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Autores principales:	Petter Holland, Helene Knævelsrud, Kristiane Søreng, Benan J. Mathai, Alf Håkon Lystad, Serhiy Pankiv, Gunnveig T. Bjørndal, Sebastian W. Schultz, Viola H. Lobert, Robin B. Chan, Bowen Zhou, Knut Liestøl, Sven R. Carlsson, Thomas J. Melia, Gilbert Di Paolo, Anne Simonsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c
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spelling	oai:doaj.org-article:f353cc30440843249f823e8e4c1b2f7c2021-12-02T14:38:56ZHS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels10.1038/ncomms138892041-1723https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13889https://doaj.org/toc/2041-1723Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization of the PA-producing enzyme phospholipase D1.Petter HollandHelene KnævelsrudKristiane SørengBenan J. MathaiAlf Håkon LystadSerhiy PankivGunnveig T. BjørndalSebastian W. SchultzViola H. LobertRobin B. ChanBowen ZhouKnut LiestølSven R. CarlssonThomas J. MeliaGilbert Di PaoloAnne SimonsenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petter Holland Helene Knævelsrud Kristiane Søreng Benan J. Mathai Alf Håkon Lystad Serhiy Pankiv Gunnveig T. Bjørndal Sebastian W. Schultz Viola H. Lobert Robin B. Chan Bowen Zhou Knut Liestøl Sven R. Carlsson Thomas J. Melia Gilbert Di Paolo Anne Simonsen HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
description	Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization of the PA-producing enzyme phospholipase D1.
format	article
author	Petter Holland Helene Knævelsrud Kristiane Søreng Benan J. Mathai Alf Håkon Lystad Serhiy Pankiv Gunnveig T. Bjørndal Sebastian W. Schultz Viola H. Lobert Robin B. Chan Bowen Zhou Knut Liestøl Sven R. Carlsson Thomas J. Melia Gilbert Di Paolo Anne Simonsen
author_facet	Petter Holland Helene Knævelsrud Kristiane Søreng Benan J. Mathai Alf Håkon Lystad Serhiy Pankiv Gunnveig T. Bjørndal Sebastian W. Schultz Viola H. Lobert Robin B. Chan Bowen Zhou Knut Liestøl Sven R. Carlsson Thomas J. Melia Gilbert Di Paolo Anne Simonsen
author_sort	Petter Holland
title	HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
title_short	HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
title_full	HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
title_fullStr	HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
title_full_unstemmed	HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
title_sort	hs1bp3 negatively regulates autophagy by modulation of phosphatidic acid levels
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c
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HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

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