HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

Autophagy must be tightly controlled at each step of the process. Here the authors show that HS1BP3 binds phosphatidic acid (PA) at autophagosome precursors and negatively regulates autophagosome formation by modulating the activity and localization of the PA-producing enzyme phospholipase D1.

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Auteurs principaux: Petter Holland, Helene Knævelsrud, Kristiane Søreng, Benan J. Mathai, Alf Håkon Lystad, Serhiy Pankiv, Gunnveig T. Bjørndal, Sebastian W. Schultz, Viola H. Lobert, Robin B. Chan, Bowen Zhou, Knut Liestøl, Sven R. Carlsson, Thomas J. Melia, Gilbert Di Paolo, Anne Simonsen
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Science
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Accès en ligne:https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c
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Internet

https://doaj.org/article/f353cc30440843249f823e8e4c1b2f7c

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