On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398
ABSTRACT The recent study by L. Price et al. [mBio, 3(1):e00305-11, 2012] demonstrating the human origin of the livestock-associated CC398 Staphylococcus aureus provides an excellent example of how bacterial populations can explore a wide range of potential niches and acquire optimal adaptations for...
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American Society for Microbiology
2012
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oai:doaj.org-article:f35578b4a9954836b34bc219a6fde95a2021-11-15T15:39:09ZOn the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC39810.1128/mBio.00078-122150-7511https://doaj.org/article/f35578b4a9954836b34bc219a6fde95a2012-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00078-12https://doaj.org/toc/2150-7511ABSTRACT The recent study by L. Price et al. [mBio, 3(1):e00305-11, 2012] demonstrating the human origin of the livestock-associated CC398 Staphylococcus aureus provides an excellent example of how bacterial populations can explore a wide range of potential niches and acquire optimal adaptations for life in alternative hosts. The shifting balance theory proposed by Sewall Wright 80 years ago serves as a perfect model for understanding the observed facts: a possibly large CC398 population optimally positioned on the top of a fitness peak for living in a human host probably began evolving long ago by variation, drift, and migration, until it reached the low fitness edge of a neighboring alternative peak in the fitness landscape, one in a livestock host. The bacterial population then evolved again, moving uphill to reach a novel optimal “top of the peak” position in livestock. In the case of CC398, it is worrisome to think that it might readapt to human hosts without losing fitness in livestock; a double-host-adapted organism could certainly be in an optimal position for increasing its virulence and antibiotic resistance.Fernando BaqueroAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 2 (2012) |
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DOAJ |
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Microbiology QR1-502 |
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Microbiology QR1-502 Fernando Baquero On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| description |
ABSTRACT The recent study by L. Price et al. [mBio, 3(1):e00305-11, 2012] demonstrating the human origin of the livestock-associated CC398 Staphylococcus aureus provides an excellent example of how bacterial populations can explore a wide range of potential niches and acquire optimal adaptations for life in alternative hosts. The shifting balance theory proposed by Sewall Wright 80 years ago serves as a perfect model for understanding the observed facts: a possibly large CC398 population optimally positioned on the top of a fitness peak for living in a human host probably began evolving long ago by variation, drift, and migration, until it reached the low fitness edge of a neighboring alternative peak in the fitness landscape, one in a livestock host. The bacterial population then evolved again, moving uphill to reach a novel optimal “top of the peak” position in livestock. In the case of CC398, it is worrisome to think that it might readapt to human hosts without losing fitness in livestock; a double-host-adapted organism could certainly be in an optimal position for increasing its virulence and antibiotic resistance. |
| format |
article |
| author |
Fernando Baquero |
| author_facet |
Fernando Baquero |
| author_sort |
Fernando Baquero |
| title |
On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| title_short |
On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| title_full |
On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| title_fullStr |
On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| title_full_unstemmed |
On the Shifting Balance: the Case of <named-content content-type="genus-species">Staphylococcus aureus</named-content> CC398 |
| title_sort |
on the shifting balance: the case of <named-content content-type="genus-species">staphylococcus aureus</named-content> cc398 |
| publisher |
American Society for Microbiology |
| publishDate |
2012 |
| url |
https://doaj.org/article/f35578b4a9954836b34bc219a6fde95a |
| work_keys_str_mv |
AT fernandobaquero ontheshiftingbalancethecaseofnamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentcc398 |
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