Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.

<h4>Background</h4>Streptococcus suis infections are a serious problem for both humans and pigs worldwide. The emergence and increasing prevalence of antibiotic-resistant S. suis strains pose significant clinical and societal challenges.<h4>Results</h4>In our study, we sequen...

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Autores principales:	Pan Hu, Ming Yang, Anding Zhang, Jiayan Wu, Bo Chen, Yafeng Hua, Jun Yu, Huanchun Chen, Jingfa Xiao, Meilin Jin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f35609cb474b42f688ae15aada4263a9
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spelling	oai:doaj.org-article:f35609cb474b42f688ae15aada4263a92021-11-04T06:07:50ZComparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.1932-620310.1371/journal.pone.0024988https://doaj.org/article/f35609cb474b42f688ae15aada4263a92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966396/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Streptococcus suis infections are a serious problem for both humans and pigs worldwide. The emergence and increasing prevalence of antibiotic-resistant S. suis strains pose significant clinical and societal challenges.<h4>Results</h4>In our study, we sequenced one multi-drug-resistant S. suis strain, R61, and one S. suis strain, A7, which is fully sensitive to all tested antibiotics. Comparative genomic analysis revealed that the R61 strain is phylogenetically distinct from other S. suis strains, and the genome of R61 exhibits extreme levels of evolutionary plasticity with high levels of gene gain and loss. Our results indicate that the multi-drug-resistant strain R61 has evolved three main categories of resistance.<h4>Conclusions</h4>Comparative genomic analysis of S. suis strains with diverse drug-resistant phenotypes provided evidence that horizontal gene transfer is an important evolutionary force in shaping the genome of multi-drug-resistant strain R61. In this study, we discovered novel and previously unexamined mutations that are strong candidates for conferring drug resistance. We believe that these mutations will provide crucial clues for designing new drugs against this pathogen. In addition, our work provides a clear demonstration that the use of drugs has driven the emergence of the multi-drug-resistant strain R61.Pan HuMing YangAnding ZhangJiayan WuBo ChenYafeng HuaJun YuHuanchun ChenJingfa XiaoMeilin JinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24988 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pan Hu Ming Yang Anding Zhang Jiayan Wu Bo Chen Yafeng Hua Jun Yu Huanchun Chen Jingfa Xiao Meilin Jin Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
description	<h4>Background</h4>Streptococcus suis infections are a serious problem for both humans and pigs worldwide. The emergence and increasing prevalence of antibiotic-resistant S. suis strains pose significant clinical and societal challenges.<h4>Results</h4>In our study, we sequenced one multi-drug-resistant S. suis strain, R61, and one S. suis strain, A7, which is fully sensitive to all tested antibiotics. Comparative genomic analysis revealed that the R61 strain is phylogenetically distinct from other S. suis strains, and the genome of R61 exhibits extreme levels of evolutionary plasticity with high levels of gene gain and loss. Our results indicate that the multi-drug-resistant strain R61 has evolved three main categories of resistance.<h4>Conclusions</h4>Comparative genomic analysis of S. suis strains with diverse drug-resistant phenotypes provided evidence that horizontal gene transfer is an important evolutionary force in shaping the genome of multi-drug-resistant strain R61. In this study, we discovered novel and previously unexamined mutations that are strong candidates for conferring drug resistance. We believe that these mutations will provide crucial clues for designing new drugs against this pathogen. In addition, our work provides a clear demonstration that the use of drugs has driven the emergence of the multi-drug-resistant strain R61.
format	article
author	Pan Hu Ming Yang Anding Zhang Jiayan Wu Bo Chen Yafeng Hua Jun Yu Huanchun Chen Jingfa Xiao Meilin Jin
author_facet	Pan Hu Ming Yang Anding Zhang Jiayan Wu Bo Chen Yafeng Hua Jun Yu Huanchun Chen Jingfa Xiao Meilin Jin
author_sort	Pan Hu
title	Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
title_short	Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
title_full	Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
title_fullStr	Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
title_full_unstemmed	Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.
title_sort	comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant streptococcus suis r61 strain.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f35609cb474b42f688ae15aada4263a9
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Comparative genomics study of multi-drug-resistance mechanisms in the antibiotic-resistant Streptococcus suis R61 strain.

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