A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

Understanding the human antibody response to influenza A virus strains is important for vaccine development. Here, Creanga et al. generate a panel of 55 replication-deficient reporter viruses representing diversity of human H1N1 and H3N2, and pandemic subtypes and characterize the neutralization pro...

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Autores principales:	Adrian Creanga, Rebecca A. Gillespie, Brian E. Fisher, Sarah F. Andrews, Julia Lederhofer, Christina Yap, Liam Hatch, Tyler Stephens, Yaroslav Tsybovsky, Michelle C. Crank, Julie E. Ledgerwood, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f356614b040e47ff842a80b70937a8bb
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spelling	oai:doaj.org-article:f356614b040e47ff842a80b70937a8bb2021-12-02T13:17:39ZA comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies10.1038/s41467-021-21954-22041-1723https://doaj.org/article/f356614b040e47ff842a80b70937a8bb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21954-2https://doaj.org/toc/2041-1723Understanding the human antibody response to influenza A virus strains is important for vaccine development. Here, Creanga et al. generate a panel of 55 replication-deficient reporter viruses representing diversity of human H1N1 and H3N2, and pandemic subtypes and characterize the neutralization profile of 24 antibodies and polyclonal sera.Adrian CreangaRebecca A. GillespieBrian E. FisherSarah F. AndrewsJulia LederhoferChristina YapLiam HatchTyler StephensYaroslav TsybovskyMichelle C. CrankJulie E. LedgerwoodAdrian B. McDermottJohn R. MascolaBarney S. GrahamMasaru KanekiyoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrian Creanga Rebecca A. Gillespie Brian E. Fisher Sarah F. Andrews Julia Lederhofer Christina Yap Liam Hatch Tyler Stephens Yaroslav Tsybovsky Michelle C. Crank Julie E. Ledgerwood Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
description	Understanding the human antibody response to influenza A virus strains is important for vaccine development. Here, Creanga et al. generate a panel of 55 replication-deficient reporter viruses representing diversity of human H1N1 and H3N2, and pandemic subtypes and characterize the neutralization profile of 24 antibodies and polyclonal sera.
format	article
author	Adrian Creanga Rebecca A. Gillespie Brian E. Fisher Sarah F. Andrews Julia Lederhofer Christina Yap Liam Hatch Tyler Stephens Yaroslav Tsybovsky Michelle C. Crank Julie E. Ledgerwood Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo
author_facet	Adrian Creanga Rebecca A. Gillespie Brian E. Fisher Sarah F. Andrews Julia Lederhofer Christina Yap Liam Hatch Tyler Stephens Yaroslav Tsybovsky Michelle C. Crank Julie E. Ledgerwood Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo
author_sort	Adrian Creanga
title	A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
title_short	A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
title_full	A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
title_fullStr	A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
title_full_unstemmed	A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
title_sort	comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f356614b040e47ff842a80b70937a8bb
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A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

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