Correction of amblyopia in cats and mice after the critical period

Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later in life when the non-deprived (fellow) eye is remo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ming-fai Fong, Kevin R Duffy, Madison P Leet, Christian T Candler, Mark F Bear
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	cat amblyopia tetrodotoxin monocular deprivation metaplasticity ocular dominance plasticity Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f35720d382314c868ccdd3503f5c3c57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f35720d382314c868ccdd3503f5c3c57
record_format	dspace
spelling	oai:doaj.org-article:f35720d382314c868ccdd3503f5c3c572021-12-01T10:53:34ZCorrection of amblyopia in cats and mice after the critical period10.7554/eLife.700232050-084Xe70023https://doaj.org/article/f35720d382314c868ccdd3503f5c3c572021-08-01T00:00:00Zhttps://elifesciences.org/articles/70023https://doaj.org/toc/2050-084XMonocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later in life when the non-deprived (fellow) eye is removed. The traditional interpretation of this finding is that vision is improved simply by the elimination of interocular suppression in primary visual cortex, revealing responses to previously subthreshold input. However, an alternative explanation is that silencing activity in the fellow eye establishes conditions in visual cortex that enable the weak connections from the amblyopic eye to gain strength, in which case the recovery would persist even if vision is restored in the fellow eye. Consistent with this idea, we show here in cats and mice that temporary inactivation of the fellow eye is sufficient to promote a full and enduring recovery from amblyopia at ages when conventional treatments fail. Thus, connections serving the amblyopic eye are capable of substantial plasticity beyond the critical period, and this potential is unleashed by reversibly silencing the fellow eye.Ming-fai FongKevin R DuffyMadison P LeetChristian T CandlerMark F BeareLife Sciences Publications Ltdarticlecatamblyopiatetrodotoxinmonocular deprivationmetaplasticityocular dominance plasticityMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cat amblyopia tetrodotoxin monocular deprivation metaplasticity ocular dominance plasticity Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	cat amblyopia tetrodotoxin monocular deprivation metaplasticity ocular dominance plasticity Medicine R Science Q Biology (General) QH301-705.5 Ming-fai Fong Kevin R Duffy Madison P Leet Christian T Candler Mark F Bear Correction of amblyopia in cats and mice after the critical period
description	Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later in life when the non-deprived (fellow) eye is removed. The traditional interpretation of this finding is that vision is improved simply by the elimination of interocular suppression in primary visual cortex, revealing responses to previously subthreshold input. However, an alternative explanation is that silencing activity in the fellow eye establishes conditions in visual cortex that enable the weak connections from the amblyopic eye to gain strength, in which case the recovery would persist even if vision is restored in the fellow eye. Consistent with this idea, we show here in cats and mice that temporary inactivation of the fellow eye is sufficient to promote a full and enduring recovery from amblyopia at ages when conventional treatments fail. Thus, connections serving the amblyopic eye are capable of substantial plasticity beyond the critical period, and this potential is unleashed by reversibly silencing the fellow eye.
format	article
author	Ming-fai Fong Kevin R Duffy Madison P Leet Christian T Candler Mark F Bear
author_facet	Ming-fai Fong Kevin R Duffy Madison P Leet Christian T Candler Mark F Bear
author_sort	Ming-fai Fong
title	Correction of amblyopia in cats and mice after the critical period
title_short	Correction of amblyopia in cats and mice after the critical period
title_full	Correction of amblyopia in cats and mice after the critical period
title_fullStr	Correction of amblyopia in cats and mice after the critical period
title_full_unstemmed	Correction of amblyopia in cats and mice after the critical period
title_sort	correction of amblyopia in cats and mice after the critical period
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/f35720d382314c868ccdd3503f5c3c57
work_keys_str_mv	AT mingfaifong correctionofamblyopiaincatsandmiceafterthecriticalperiod AT kevinrduffy correctionofamblyopiaincatsandmiceafterthecriticalperiod AT madisonpleet correctionofamblyopiaincatsandmiceafterthecriticalperiod AT christiantcandler correctionofamblyopiaincatsandmiceafterthecriticalperiod AT markfbear correctionofamblyopiaincatsandmiceafterthecriticalperiod
_version_	1718405269838364672

Correction of amblyopia in cats and mice after the critical period

Ejemplares similares