The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma

Purpose: To investigate the clinical significance of vessel density (VD) on visual field (VF) progression regarding the severity of glaucoma. Methods: A total of 130 eyes were recruited in this retrospective and longitudinal study. Superficial and deep VDs in circumpapillary and macular regions were...

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Autores principales:	Jiyun Lee, Chan Kee Park, Hae-Young Lopilly Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	optical coherence tomography angiography advanced glaucoma superficial vessel density visual field progression Medicine R
Acceso en línea:	https://doaj.org/article/f35781d263ee41c5a2f22b8f30299871
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spelling	oai:doaj.org-article:f35781d263ee41c5a2f22b8f302998712021-11-11T17:46:11ZThe Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma10.3390/jcm102151502077-0383https://doaj.org/article/f35781d263ee41c5a2f22b8f302998712021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5150https://doaj.org/toc/2077-0383Purpose: To investigate the clinical significance of vessel density (VD) on visual field (VF) progression regarding the severity of glaucoma. Methods: A total of 130 eyes were recruited in this retrospective and longitudinal study. Superficial and deep VDs in circumpapillary and macular regions were measured via ImageJ. The rate of VF progression was defined as the mean deviation (MD) slope (dB/year). Linear regression was used to verify factors affecting deterioration of VF. The eyes with lower superficial VD were further analyzed. Results: Fifty patients with early glaucoma (EG) (MD > −6 dB) and 52 patients with moderate-to-advanced glaucoma (MAG) (MD ≤ −6 dB) were included. A faster progression rate was found in MAG (<i>p</i> = 0.049). Superficial VD was noticeably related to the VF progression rate in total eyes and in MAG (Both Ps ≤ 0.007, respectively). With patients in the lower half of the superficial VD, the VD was significantly associated with the rate of progression (B, 0.049, <i>p</i> = 0.021). This association was independent of the baseline MD and OCT parameters. Conclusion: Decreased superficial VD might conversely affect the progression of glaucoma even in MAG, which suggests superficial VD could be used as a potential marker to foresee the disease progression even in progressed eyes.Jiyun LeeChan Kee ParkHae-Young Lopilly ParkMDPI AGarticleoptical coherence tomography angiographyadvanced glaucomasuperficial vessel densityvisual field progressionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5150, p 5150 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography angiography advanced glaucoma superficial vessel density visual field progression Medicine R
spellingShingle	optical coherence tomography angiography advanced glaucoma superficial vessel density visual field progression Medicine R Jiyun Lee Chan Kee Park Hae-Young Lopilly Park The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
description	Purpose: To investigate the clinical significance of vessel density (VD) on visual field (VF) progression regarding the severity of glaucoma. Methods: A total of 130 eyes were recruited in this retrospective and longitudinal study. Superficial and deep VDs in circumpapillary and macular regions were measured via ImageJ. The rate of VF progression was defined as the mean deviation (MD) slope (dB/year). Linear regression was used to verify factors affecting deterioration of VF. The eyes with lower superficial VD were further analyzed. Results: Fifty patients with early glaucoma (EG) (MD > −6 dB) and 52 patients with moderate-to-advanced glaucoma (MAG) (MD ≤ −6 dB) were included. A faster progression rate was found in MAG (<i>p</i> = 0.049). Superficial VD was noticeably related to the VF progression rate in total eyes and in MAG (Both Ps ≤ 0.007, respectively). With patients in the lower half of the superficial VD, the VD was significantly associated with the rate of progression (B, 0.049, <i>p</i> = 0.021). This association was independent of the baseline MD and OCT parameters. Conclusion: Decreased superficial VD might conversely affect the progression of glaucoma even in MAG, which suggests superficial VD could be used as a potential marker to foresee the disease progression even in progressed eyes.
format	article
author	Jiyun Lee Chan Kee Park Hae-Young Lopilly Park
author_facet	Jiyun Lee Chan Kee Park Hae-Young Lopilly Park
author_sort	Jiyun Lee
title	The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
title_short	The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
title_full	The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
title_fullStr	The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
title_full_unstemmed	The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma
title_sort	impact of superficial vessel density on glaucoma progression according to the stage of glaucoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f35781d263ee41c5a2f22b8f30299871
work_keys_str_mv	AT jiyunlee theimpactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma AT chankeepark theimpactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma AT haeyounglopillypark theimpactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma AT jiyunlee impactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma AT chankeepark impactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma AT haeyounglopillypark impactofsuperficialvesseldensityonglaucomaprogressionaccordingtothestageofglaucoma
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The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma

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