YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis rescues extracellular Aβ aggregation and symptoms in a...
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Nature Portfolio
2020
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oai:doaj.org-article:f3578dfd2ff148919a9dde2c540ddafd2021-12-02T14:41:15ZYAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology10.1038/s41467-020-14353-62041-1723https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14353-6https://doaj.org/toc/2041-1723The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis rescues extracellular Aβ aggregation and symptoms in a mouse model.Hikari TanakaHidenori HommaKyota FujitaKanoh KondoShingo YamadaXiaocen JinMasaaki WaragaiGaku OhtomoAtsushi IwataKazuhiko TagawaNaoki AtsutaMasahisa KatsunoNaoki TomitaKatsutoshi FurukawaYuko SaitoTakashi SaitoAyaka IchiseShinsuke ShibataHiroyuki AraiTakaomi SaidoMarius SudolShin-ichi MuramatsuHideyuki OkanoElliott J. MufsonGen SobueShigeo MurayamaHitoshi OkazawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-22 (2020) |
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Science Q Hikari Tanaka Hidenori Homma Kyota Fujita Kanoh Kondo Shingo Yamada Xiaocen Jin Masaaki Waragai Gaku Ohtomo Atsushi Iwata Kazuhiko Tagawa Naoki Atsuta Masahisa Katsuno Naoki Tomita Katsutoshi Furukawa Yuko Saito Takashi Saito Ayaka Ichise Shinsuke Shibata Hiroyuki Arai Takaomi Saido Marius Sudol Shin-ichi Muramatsu Hideyuki Okano Elliott J. Mufson Gen Sobue Shigeo Murayama Hitoshi Okazawa YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| description |
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis rescues extracellular Aβ aggregation and symptoms in a mouse model. |
| format |
article |
| author |
Hikari Tanaka Hidenori Homma Kyota Fujita Kanoh Kondo Shingo Yamada Xiaocen Jin Masaaki Waragai Gaku Ohtomo Atsushi Iwata Kazuhiko Tagawa Naoki Atsuta Masahisa Katsuno Naoki Tomita Katsutoshi Furukawa Yuko Saito Takashi Saito Ayaka Ichise Shinsuke Shibata Hiroyuki Arai Takaomi Saido Marius Sudol Shin-ichi Muramatsu Hideyuki Okano Elliott J. Mufson Gen Sobue Shigeo Murayama Hitoshi Okazawa |
| author_facet |
Hikari Tanaka Hidenori Homma Kyota Fujita Kanoh Kondo Shingo Yamada Xiaocen Jin Masaaki Waragai Gaku Ohtomo Atsushi Iwata Kazuhiko Tagawa Naoki Atsuta Masahisa Katsuno Naoki Tomita Katsutoshi Furukawa Yuko Saito Takashi Saito Ayaka Ichise Shinsuke Shibata Hiroyuki Arai Takaomi Saido Marius Sudol Shin-ichi Muramatsu Hideyuki Okano Elliott J. Mufson Gen Sobue Shigeo Murayama Hitoshi Okazawa |
| author_sort |
Hikari Tanaka |
| title |
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| title_short |
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| title_full |
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| title_fullStr |
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| title_full_unstemmed |
YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology |
| title_sort |
yap-dependent necrosis occurs in early stages of alzheimer’s disease and regulates mouse model pathology |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd |
| work_keys_str_mv |
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