Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children

Abstract Background RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kinetics of RTS,S/AS01-induced antibodies was investig...

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Autores principales:	Robert M. Mugo, Kennedy Mwai, Jedidah Mwacharo, Faiz M. Shee, Jennifer N. Musyoki, Juliana Wambua, Edward Otieno, Philip Bejon, Francis M. Ndungu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	RTS,S/AS01 Vaccines Antibodies Plasmodium falciparum Circumsporozoite protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f3598ba2fe95427294830402b185dbef
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spelling	oai:doaj.org-article:f3598ba2fe95427294830402b185dbef2021-12-05T12:21:35ZSeven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children10.1186/s12936-021-03961-21475-2875https://doaj.org/article/f3598ba2fe95427294830402b185dbef2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12936-021-03961-2https://doaj.org/toc/1475-2875Abstract Background RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kinetics of RTS,S/AS01-induced antibodies was investigated. Methods 150 participants were randomly selected from the 447 children who participated in the RTS,S/AS01 phase IIb clinical trial in 2007 from Kilifi-Kenya. Cumulatively, the retrospective follow-up period was 93 months with annual plasma samples collection. The levels of anti-CSP IgM, total IgG, IgG1, IgG2, IgG3, and IgG4 antibodies were then determined using an enzyme-linked immunosorbent assay. Results RTS,S/AS01 induced high levels of anti-CSP IgG antibodies which exhibited a rapid waning over 6.5 months post-vaccination, followed by a slower decay over the subsequent years. RTS,S/AS01-induced anti-CSP IgG antibodies remained elevated above the control group levels throughout the 7 years follow-up period. The anti-CSP IgG antibodies were mostly IgG1, IgG3, IgG2, and to a lesser extent IgG4. IgG2 predominated in later timepoints. RTS,S/AS01 also induced high levels of anti-CSP IgM antibodies which increased above the control group levels by month 3. The controls exhibited increasing levels of the anti-CSP IgM antibodies which caught up with the RTS,S/AS01 vaccinees levels by month 21. In contrast, there were no measurable anti-CSP IgG antibodies among the controls. Conclusion RTS,S/AS01-induced anti-CSP IgG antibodies kinetics are consistent with long-lived but waning vaccine efficacy. Natural exposure induces anti-CSP IgM antibodies in children, which increases with age, but does not induce substantial levels of anti-CSP IgG antibodies.Robert M. MugoKennedy MwaiJedidah MwacharoFaiz M. SheeJennifer N. MusyokiJuliana WambuaEdward OtienoPhilip BejonFrancis M. NdunguBMCarticleRTS,S/AS01VaccinesAntibodiesPlasmodium falciparumCircumsporozoite proteinArctic medicine. Tropical medicineRC955-962Infectious and parasitic diseasesRC109-216ENMalaria Journal, Vol 20, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RTS,S/AS01 Vaccines Antibodies Plasmodium falciparum Circumsporozoite protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
spellingShingle	RTS,S/AS01 Vaccines Antibodies Plasmodium falciparum Circumsporozoite protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Robert M. Mugo Kennedy Mwai Jedidah Mwacharo Faiz M. Shee Jennifer N. Musyoki Juliana Wambua Edward Otieno Philip Bejon Francis M. Ndungu Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
description	Abstract Background RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kinetics of RTS,S/AS01-induced antibodies was investigated. Methods 150 participants were randomly selected from the 447 children who participated in the RTS,S/AS01 phase IIb clinical trial in 2007 from Kilifi-Kenya. Cumulatively, the retrospective follow-up period was 93 months with annual plasma samples collection. The levels of anti-CSP IgM, total IgG, IgG1, IgG2, IgG3, and IgG4 antibodies were then determined using an enzyme-linked immunosorbent assay. Results RTS,S/AS01 induced high levels of anti-CSP IgG antibodies which exhibited a rapid waning over 6.5 months post-vaccination, followed by a slower decay over the subsequent years. RTS,S/AS01-induced anti-CSP IgG antibodies remained elevated above the control group levels throughout the 7 years follow-up period. The anti-CSP IgG antibodies were mostly IgG1, IgG3, IgG2, and to a lesser extent IgG4. IgG2 predominated in later timepoints. RTS,S/AS01 also induced high levels of anti-CSP IgM antibodies which increased above the control group levels by month 3. The controls exhibited increasing levels of the anti-CSP IgM antibodies which caught up with the RTS,S/AS01 vaccinees levels by month 21. In contrast, there were no measurable anti-CSP IgG antibodies among the controls. Conclusion RTS,S/AS01-induced anti-CSP IgG antibodies kinetics are consistent with long-lived but waning vaccine efficacy. Natural exposure induces anti-CSP IgM antibodies in children, which increases with age, but does not induce substantial levels of anti-CSP IgG antibodies.
format	article
author	Robert M. Mugo Kennedy Mwai Jedidah Mwacharo Faiz M. Shee Jennifer N. Musyoki Juliana Wambua Edward Otieno Philip Bejon Francis M. Ndungu
author_facet	Robert M. Mugo Kennedy Mwai Jedidah Mwacharo Faiz M. Shee Jennifer N. Musyoki Juliana Wambua Edward Otieno Philip Bejon Francis M. Ndungu
author_sort	Robert M. Mugo
title	Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
title_short	Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
title_full	Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
title_fullStr	Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
title_full_unstemmed	Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
title_sort	seven-year kinetics of rts, s/as01-induced anti-csp antibodies in young kenyan children
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f3598ba2fe95427294830402b185dbef
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Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children

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