Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly

Background: Several various physiological functions in elderly people are diminished due to cell or tissue damage. One of the probable causes are oxidative stress yielded by free radicals. Oxidative stress (ROS) induce lipid peroxidation in endothelial cell membrane, which generates atherosclerotic...

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Autores principales:	Dwi Ngestiningsih, Rejeki Andayani Rahayu, Lusiana Batubara
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2019
Materias:	sod mda total cholesterol ldl cholesterol Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f35b10f7f19645638e5e7d928a84e453
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spelling	oai:doaj.org-article:f35b10f7f19645638e5e7d928a84e4532021-11-05T16:47:32ZEffect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly2503-217810.14710/jbtr.v5i2.4679https://doaj.org/article/f35b10f7f19645638e5e7d928a84e4532019-12-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/4679https://doaj.org/toc/2503-2178Background: Several various physiological functions in elderly people are diminished due to cell or tissue damage. One of the probable causes are oxidative stress yielded by free radicals. Oxidative stress (ROS) induce lipid peroxidation in endothelial cell membrane, which generates atherosclerotic plaque. In a state of oxidative stress, MDA level will increased. The purpose of this study is to determine the effect of SOD supplementation on MDA, total cholesterol and LDL cholesterol plasma levels in the elderly. Methods: This study was open label, a randomized control trial. Subjects were elderly people aged > 60 years (median 75, 60-82 ys, male 10 (24,4%)) institutionalized at Social Rehabilitation Unit Pucang Gading Semarang, Indonesia. The treatment group consisted of 16 people, received SOD (GlisodinR) 1 capsule (250 IU) 1 hour before meals, plus exercise scheduled for 8 weeks. The control group consisted of 15 people, received placebo, and exercise. Plasma MDA levels were examined using TBARS method, while total cholesterol and LDL cholesterol were examined using CHOD-PAP method. Results: This study show a reduction of plasma MDA levels in the treatment group compare to control group ( p = 0.062 ). A significant reduction of total cholesterol and LDL cholesterol levels in the treatment group were found (before 190.00 and 131.47 g/dl, after 182.27 and 121.93 g/dl, p = 0.005 and 0.001). Conclusion: The SOD supplementation significantly reduce Total Cholesterol and LDL level, but not MDA level in the elderly.Dwi NgestiningsihRejeki Andayani RahayuLusiana BatubaraDiponegoro Universityarticlesodmdatotal cholesterolldl cholesterolMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 5, Iss 2, Pp 29-33 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	sod mda total cholesterol ldl cholesterol Medicine (General) R5-920
spellingShingle	sod mda total cholesterol ldl cholesterol Medicine (General) R5-920 Dwi Ngestiningsih Rejeki Andayani Rahayu Lusiana Batubara Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
description	Background: Several various physiological functions in elderly people are diminished due to cell or tissue damage. One of the probable causes are oxidative stress yielded by free radicals. Oxidative stress (ROS) induce lipid peroxidation in endothelial cell membrane, which generates atherosclerotic plaque. In a state of oxidative stress, MDA level will increased. The purpose of this study is to determine the effect of SOD supplementation on MDA, total cholesterol and LDL cholesterol plasma levels in the elderly. Methods: This study was open label, a randomized control trial. Subjects were elderly people aged > 60 years (median 75, 60-82 ys, male 10 (24,4%)) institutionalized at Social Rehabilitation Unit Pucang Gading Semarang, Indonesia. The treatment group consisted of 16 people, received SOD (GlisodinR) 1 capsule (250 IU) 1 hour before meals, plus exercise scheduled for 8 weeks. The control group consisted of 15 people, received placebo, and exercise. Plasma MDA levels were examined using TBARS method, while total cholesterol and LDL cholesterol were examined using CHOD-PAP method. Results: This study show a reduction of plasma MDA levels in the treatment group compare to control group ( p = 0.062 ). A significant reduction of total cholesterol and LDL cholesterol levels in the treatment group were found (before 190.00 and 131.47 g/dl, after 182.27 and 121.93 g/dl, p = 0.005 and 0.001). Conclusion: The SOD supplementation significantly reduce Total Cholesterol and LDL level, but not MDA level in the elderly.
format	article
author	Dwi Ngestiningsih Rejeki Andayani Rahayu Lusiana Batubara
author_facet	Dwi Ngestiningsih Rejeki Andayani Rahayu Lusiana Batubara
author_sort	Dwi Ngestiningsih
title	Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
title_short	Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
title_full	Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
title_fullStr	Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
title_full_unstemmed	Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly
title_sort	effect of superoxide dismutase (sod) supplementation on plasma levels of malondialdehyde (mda), total cholesterol and ldl cholesterol in the elderly
publisher	Diponegoro University
publishDate	2019
url	https://doaj.org/article/f35b10f7f19645638e5e7d928a84e453
work_keys_str_mv	AT dwingestiningsih effectofsuperoxidedismutasesodsupplementationonplasmalevelsofmalondialdehydemdatotalcholesterolandldlcholesterolintheelderly AT rejekiandayanirahayu effectofsuperoxidedismutasesodsupplementationonplasmalevelsofmalondialdehydemdatotalcholesterolandldlcholesterolintheelderly AT lusianabatubara effectofsuperoxidedismutasesodsupplementationonplasmalevelsofmalondialdehydemdatotalcholesterolandldlcholesterolintheelderly
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Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly

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