Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain

Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain

It is generally believed that a successful Zika virus (ZIKV) vaccine should induce neutralizing antibodies against the ZIKV envelope (E) protein to efficiently halt viral infection. However, E-specific neutralizing antibodies have been implicated in a phenomenon called antibody-dependent enhancement...

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Bibliographic Details
Main Authors: Loulieta Nazerai, Søren Buus, Anette Stryhn, Allan Randrup Thomsen, Jan Pravsgaard Christensen
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
Zika virus
vaccine
NS1/NS2
CD8 T cell response
MHC-II invariant chain
Microbiology
QR1-502
Online Access:https://doaj.org/article/f35c58cfd4ae4020b4a0433eafa35e0c
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https://doaj.org/article/f35c58cfd4ae4020b4a0433eafa35e0c

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