Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?

The sequestration of Plasmodium falciparum-infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study. In contrast to P. falciparum, much less is known about sequestration in...

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Autores principales:	Blandine Franke-Fayard, Jannik Fonager, Anneke Braks, Shahid M Khan, Chris J Janse
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f36196cf5b1f44e2b800df56eb7595e2
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spelling	oai:doaj.org-article:f36196cf5b1f44e2b800df56eb7595e22021-11-18T06:03:52ZSequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?1553-73661553-737410.1371/journal.ppat.1001032https://doaj.org/article/f36196cf5b1f44e2b800df56eb7595e22010-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941396/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The sequestration of Plasmodium falciparum-infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study. In contrast to P. falciparum, much less is known about sequestration in other Plasmodium parasites, including those species that are used as models to study severe malaria. Here, we review the cytoadherence properties of irbcs of the rodent parasite Plasmodium berghei ANKA, where schizonts demonstrate a clear sequestration phenotype. Real-time in vivo imaging of transgenic P. berghei parasites in rodents has revealed a CD36-dependent sequestration in lungs and adipose tissue. In the absence of direct orthologs of the P. falciparum proteins that mediate binding to human CD36, the P. berghei proteins and/or mechanisms of rodent CD36 binding are as yet unknown. In addition to CD36-dependent schizont sequestration, irbcs accumulate during severe disease in different tissues, including the brain. The role of sequestration is discussed in the context of disease as are the general (dis)similarities of P. berghei and P. falciparum sequestration.Blandine Franke-FayardJannik FonagerAnneke BraksShahid M KhanChris J JansePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 9, p e1001032 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Blandine Franke-Fayard Jannik Fonager Anneke Braks Shahid M Khan Chris J Janse Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
description	The sequestration of Plasmodium falciparum-infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study. In contrast to P. falciparum, much less is known about sequestration in other Plasmodium parasites, including those species that are used as models to study severe malaria. Here, we review the cytoadherence properties of irbcs of the rodent parasite Plasmodium berghei ANKA, where schizonts demonstrate a clear sequestration phenotype. Real-time in vivo imaging of transgenic P. berghei parasites in rodents has revealed a CD36-dependent sequestration in lungs and adipose tissue. In the absence of direct orthologs of the P. falciparum proteins that mediate binding to human CD36, the P. berghei proteins and/or mechanisms of rodent CD36 binding are as yet unknown. In addition to CD36-dependent schizont sequestration, irbcs accumulate during severe disease in different tissues, including the brain. The role of sequestration is discussed in the context of disease as are the general (dis)similarities of P. berghei and P. falciparum sequestration.
format	article
author	Blandine Franke-Fayard Jannik Fonager Anneke Braks Shahid M Khan Chris J Janse
author_facet	Blandine Franke-Fayard Jannik Fonager Anneke Braks Shahid M Khan Chris J Janse
author_sort	Blandine Franke-Fayard
title	Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
title_short	Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
title_full	Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
title_fullStr	Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
title_full_unstemmed	Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
title_sort	sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f36196cf5b1f44e2b800df56eb7595e2
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Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?

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