The antimicrobial activity of nanoparticles: present situation and prospects for the future

Linlin Wang,1,* Chen Hu,2,* Longquan Shao2 1Department of Stomatology, Hainan General Hospital, Haikou, Hainan, 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Nano...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang LL, Hu C, Shao LQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Nanoparticles Antimicrobial Activity Oxidative stress microbial resistance Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f362a3cd5ed14f969cce1feb0207ef33
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f362a3cd5ed14f969cce1feb0207ef33
record_format	dspace
spelling	oai:doaj.org-article:f362a3cd5ed14f969cce1feb0207ef332021-12-02T05:14:21ZThe antimicrobial activity of nanoparticles: present situation and prospects for the future1178-2013https://doaj.org/article/f362a3cd5ed14f969cce1feb0207ef332017-02-01T00:00:00Zhttps://www.dovepress.com/the-antimicrobial-activity-of-nanoparticles-present-situation-and-pros-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Linlin Wang,1,* Chen Hu,2,* Longquan Shao2 1Department of Stomatology, Hainan General Hospital, Haikou, Hainan, 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed. Keywords: antimicrobial activity, nanoparticles, oxidative stress, antimicrobial resistanceWang LLHu CShao LQDove Medical PressarticleNanoparticlesAntimicrobial ActivityOxidative stressmicrobial resistanceMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1227-1249 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanoparticles Antimicrobial Activity Oxidative stress microbial resistance Medicine (General) R5-920
spellingShingle	Nanoparticles Antimicrobial Activity Oxidative stress microbial resistance Medicine (General) R5-920 Wang LL Hu C Shao LQ The antimicrobial activity of nanoparticles: present situation and prospects for the future
description	Linlin Wang,1,* Chen Hu,2,* Longquan Shao2 1Department of Stomatology, Hainan General Hospital, Haikou, Hainan, 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed. Keywords: antimicrobial activity, nanoparticles, oxidative stress, antimicrobial resistance
format	article
author	Wang LL Hu C Shao LQ
author_facet	Wang LL Hu C Shao LQ
author_sort	Wang LL
title	The antimicrobial activity of nanoparticles: present situation and prospects for the future
title_short	The antimicrobial activity of nanoparticles: present situation and prospects for the future
title_full	The antimicrobial activity of nanoparticles: present situation and prospects for the future
title_fullStr	The antimicrobial activity of nanoparticles: present situation and prospects for the future
title_full_unstemmed	The antimicrobial activity of nanoparticles: present situation and prospects for the future
title_sort	antimicrobial activity of nanoparticles: present situation and prospects for the future
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f362a3cd5ed14f969cce1feb0207ef33
work_keys_str_mv	AT wangll theantimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture AT huc theantimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture AT shaolq theantimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture AT wangll antimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture AT huc antimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture AT shaolq antimicrobialactivityofnanoparticlespresentsituationandprospectsforthefuture
_version_	1718400507020574720

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Ejemplares similares