Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene

X-linked juvenile retinoschisis (XLRS) is an inherited disease characterized by splitting within inner retinal layers and impaired vision, which begins in childhood and occurs mostly in males. Peripheral blood mononuclear cells (PBMCs) were isolated from a seven-year-old boy carrying a hemizygous mu...

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Autores principales:	Yafen Liu, Xinyu Liu, Mingwei Huang, Linyan Zhang, Jinglin Lu, Zhaotian Zhang, Xiaoyan Ding
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f36574e60f02466288246bd7ddb93651
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spelling	oai:doaj.org-article:f36574e60f02466288246bd7ddb936512021-11-18T04:46:22ZGeneration of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene1873-506110.1016/j.scr.2021.102595https://doaj.org/article/f36574e60f02466288246bd7ddb936512021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1873506121004426https://doaj.org/toc/1873-5061X-linked juvenile retinoschisis (XLRS) is an inherited disease characterized by splitting within inner retinal layers and impaired vision, which begins in childhood and occurs mostly in males. Peripheral blood mononuclear cells (PBMCs) were isolated from a seven-year-old boy carrying a hemizygous mutation in RS1 gene, and were reprogrammed into human induced pluripotent stem cells (iPSCs) using non-integrative episomal vectors. The cell line, ZOCi003-A, had normal karyotype, expressed pluripotency markers, and could differentiate into three germ layers in vivo. This IPSC line may be used for studying the molecular basis of XLRS and selecting potential therapeutic targets and drugs.Yafen LiuXinyu LiuMingwei HuangLinyan ZhangJinglin LuZhaotian ZhangXiaoyan DingElsevierarticleBiology (General)QH301-705.5ENStem Cell Research, Vol 57, Iss , Pp 102595- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yafen Liu Xinyu Liu Mingwei Huang Linyan Zhang Jinglin Lu Zhaotian Zhang Xiaoyan Ding Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
description	X-linked juvenile retinoschisis (XLRS) is an inherited disease characterized by splitting within inner retinal layers and impaired vision, which begins in childhood and occurs mostly in males. Peripheral blood mononuclear cells (PBMCs) were isolated from a seven-year-old boy carrying a hemizygous mutation in RS1 gene, and were reprogrammed into human induced pluripotent stem cells (iPSCs) using non-integrative episomal vectors. The cell line, ZOCi003-A, had normal karyotype, expressed pluripotency markers, and could differentiate into three germ layers in vivo. This IPSC line may be used for studying the molecular basis of XLRS and selecting potential therapeutic targets and drugs.
format	article
author	Yafen Liu Xinyu Liu Mingwei Huang Linyan Zhang Jinglin Lu Zhaotian Zhang Xiaoyan Ding
author_facet	Yafen Liu Xinyu Liu Mingwei Huang Linyan Zhang Jinglin Lu Zhaotian Zhang Xiaoyan Ding
author_sort	Yafen Liu
title	Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
title_short	Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
title_full	Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
title_fullStr	Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
title_full_unstemmed	Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene
title_sort	generation of induced pluripotent stem cell (ipsc) line zoci003-a derived from peripheral blood mononuclear cells of x-linked juvenile retinoschisis harboring a hemizygous mutation in rs1 gene
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f36574e60f02466288246bd7ddb93651
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Generation of induced pluripotent stem cell (iPSC) line ZOCi003-A derived from peripheral blood mononuclear cells of X-linked juvenile retinoschisis harboring a hemizygous mutation in RS1 gene

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