Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease

Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophys...

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Autores principales:	Taylor J. Bosch, Stefan Kammermeier, Christopher Groth, Matt Leedom, Elizabeth K. Hanson, Patti Berg-Poppe, Arun Singh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	postural control balance EEG oscillations theta cerebellum Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f3668453ce234f0e8394cd5a1bafbc28
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spelling	oai:doaj.org-article:f3668453ce234f0e8394cd5a1bafbc282021-11-04T05:49:13ZCortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease1664-229510.3389/fneur.2021.752271https://doaj.org/article/f3668453ce234f0e8394cd5a1bafbc282021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.752271/fullhttps://doaj.org/toc/1664-2295Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals.Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI–), and 15 age-matched healthy control participants. Relative spectral power was analyzed in the theta (4–7 Hz) and beta (13–30 Hz) frequency bands.Results: Time-dependent postural measurements computed by accelerometer signals showed poor performance in PDPI+ participants. EEG results revealed that theta power was profoundly lower in mid-frontal and mid-cerebellar regions during the postural control task in PDPI+, compared to PDPI– and control participants. In addition, theta power was correlated with postural control performance in PD subjects. No significant changes in beta power were observed. Additionally, oscillatory changes during the postural control task differed from the resting state.Conclusion: This study underlines the involvement of mid-frontal and mid-cerebellar regions in postural stability during a balance task and emphasizes the important role of theta oscillations therein for postural control in PD.Taylor J. BoschTaylor J. BoschStefan KammermeierChristopher GrothMatt LeedomElizabeth K. HansonPatti Berg-PoppeArun SinghArun SinghFrontiers Media S.A.articlepostural controlbalanceEEGoscillationsthetacerebellumNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	postural control balance EEG oscillations theta cerebellum Neurology. Diseases of the nervous system RC346-429
spellingShingle	postural control balance EEG oscillations theta cerebellum Neurology. Diseases of the nervous system RC346-429 Taylor J. Bosch Taylor J. Bosch Stefan Kammermeier Christopher Groth Matt Leedom Elizabeth K. Hanson Patti Berg-Poppe Arun Singh Arun Singh Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
description	Introduction: Posture and balance dysfunctions critically impair activities of daily living of patients with progressing Parkinson's disease (PD). However, the neural mechanisms underlying postural instability in PD are poorly understood, and specific therapies are lacking. Previous electrophysiological studies have shown distinct cortical oscillations with a significant contribution of the cerebellum during postural control tasks in healthy individuals.Methods: We investigated cortical and mid-cerebellar oscillatory activity via electroencephalography (EEG) during a postural control task in 10 PD patients with postural instability (PDPI+), 11 PD patients without postural instability (PDPI–), and 15 age-matched healthy control participants. Relative spectral power was analyzed in the theta (4–7 Hz) and beta (13–30 Hz) frequency bands.Results: Time-dependent postural measurements computed by accelerometer signals showed poor performance in PDPI+ participants. EEG results revealed that theta power was profoundly lower in mid-frontal and mid-cerebellar regions during the postural control task in PDPI+, compared to PDPI– and control participants. In addition, theta power was correlated with postural control performance in PD subjects. No significant changes in beta power were observed. Additionally, oscillatory changes during the postural control task differed from the resting state.Conclusion: This study underlines the involvement of mid-frontal and mid-cerebellar regions in postural stability during a balance task and emphasizes the important role of theta oscillations therein for postural control in PD.
format	article
author	Taylor J. Bosch Taylor J. Bosch Stefan Kammermeier Christopher Groth Matt Leedom Elizabeth K. Hanson Patti Berg-Poppe Arun Singh Arun Singh
author_facet	Taylor J. Bosch Taylor J. Bosch Stefan Kammermeier Christopher Groth Matt Leedom Elizabeth K. Hanson Patti Berg-Poppe Arun Singh Arun Singh
author_sort	Taylor J. Bosch
title	Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
title_short	Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
title_full	Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
title_fullStr	Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
title_full_unstemmed	Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease
title_sort	cortical and cerebellar oscillatory responses to postural instability in parkinson's disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f3668453ce234f0e8394cd5a1bafbc28
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Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease

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