Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.

Guardado en:

Detalles Bibliográficos
Autores principales:	Priyanka Gopal, Elif Irem Sarihan, Eui Kyu Chie, Gwendolyn Kuzmishin, Semihcan Doken, Nathan A. Pennell, Daniel P. Raymond, Sudish C. Murthy, Usman Ahmad, Siva Raja, Francisco Almeida, Sonali Sethi, Thomas R. Gildea, Craig D. Peacock, Drew J. Adams, Mohamed E. Abazeed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f366c71ec9404be4b753b8be5ed59abb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f366c71ec9404be4b753b8be5ed59abb
record_format	dspace
spelling	oai:doaj.org-article:f366c71ec9404be4b753b8be5ed59abb2021-12-02T16:57:22ZClonal selection confers distinct evolutionary trajectories in BRAF-driven cancers10.1038/s41467-019-13161-x2041-1723https://doaj.org/article/f366c71ec9404be4b753b8be5ed59abb2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13161-xhttps://doaj.org/toc/2041-1723BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.Priyanka GopalElif Irem SarihanEui Kyu ChieGwendolyn KuzmishinSemihcan DokenNathan A. PennellDaniel P. RaymondSudish C. MurthyUsman AhmadSiva RajaFrancisco AlmeidaSonali SethiThomas R. GildeaCraig D. PeacockDrew J. AdamsMohamed E. AbazeedNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Priyanka Gopal Elif Irem Sarihan Eui Kyu Chie Gwendolyn Kuzmishin Semihcan Doken Nathan A. Pennell Daniel P. Raymond Sudish C. Murthy Usman Ahmad Siva Raja Francisco Almeida Sonali Sethi Thomas R. Gildea Craig D. Peacock Drew J. Adams Mohamed E. Abazeed Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
description	BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.
format	article
author	Priyanka Gopal Elif Irem Sarihan Eui Kyu Chie Gwendolyn Kuzmishin Semihcan Doken Nathan A. Pennell Daniel P. Raymond Sudish C. Murthy Usman Ahmad Siva Raja Francisco Almeida Sonali Sethi Thomas R. Gildea Craig D. Peacock Drew J. Adams Mohamed E. Abazeed
author_facet	Priyanka Gopal Elif Irem Sarihan Eui Kyu Chie Gwendolyn Kuzmishin Semihcan Doken Nathan A. Pennell Daniel P. Raymond Sudish C. Murthy Usman Ahmad Siva Raja Francisco Almeida Sonali Sethi Thomas R. Gildea Craig D. Peacock Drew J. Adams Mohamed E. Abazeed
author_sort	Priyanka Gopal
title	Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
title_short	Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
title_full	Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
title_fullStr	Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
title_full_unstemmed	Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
title_sort	clonal selection confers distinct evolutionary trajectories in braf-driven cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f366c71ec9404be4b753b8be5ed59abb
work_keys_str_mv	AT priyankagopal clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT elifiremsarihan clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT euikyuchie clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT gwendolynkuzmishin clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT semihcandoken clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT nathanapennell clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT danielpraymond clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT sudishcmurthy clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT usmanahmad clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT sivaraja clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT franciscoalmeida clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT sonalisethi clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT thomasrgildea clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT craigdpeacock clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT drewjadams clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers AT mohamedeabazeed clonalselectionconfersdistinctevolutionarytrajectoriesinbrafdrivencancers
_version_	1718382599445938176

Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

Ejemplares similares