Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses

Abstract Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We...

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Autores principales:	Katarzyna J. Siemienowicz, Yili Wang, Magda Marečková, Junko Nio-Kobayashi, Paul A. Fowler, Mick T. Rae, W. Colin Duncan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3674f2be6cf4291a7eee02f7f0513c8
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spelling	oai:doaj.org-article:f3674f2be6cf4291a7eee02f7f0513c82021-12-02T12:42:19ZEarly pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses10.1038/s41598-020-78976-x2045-2322https://doaj.org/article/f3674f2be6cf4291a7eee02f7f0513c82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78976-xhttps://doaj.org/toc/2045-2322Abstract Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone supplementation would increase fetal progesterone, affect progesterone target tissues in the developing fetal reproductive system and be metabolised to other bioactive steroids in the fetus. We investigated the effects of progesterone treatment during early pregnancy on maternal and fetal plasma progesterone concentrations, transcript abundance in the fetal pituitary and testes and circulating steroids, at day 75 gestation, using a clinically realistic ovine model. Endogenous progesterone concentrations were lower in male than female fetuses. Maternal progesterone administration increased male, but not female, fetal progesterone concentrations, also increasing circulating 11-dehydrocorticosterone in male fetuses. Maternal progesterone administration altered fetal pituitary and testicular function in ovine male fetuses. This suggests that there may be fetal sex specific effects of the use of progesterone in early pregnancy, and highlights that progesterone supplementation should be used only when there is clear evidence of efficacy and for as limited time as necessary.Katarzyna J. SiemienowiczYili WangMagda MarečkováJunko Nio-KobayashiPaul A. FowlerMick T. RaeW. Colin DuncanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna J. Siemienowicz Yili Wang Magda Marečková Junko Nio-Kobayashi Paul A. Fowler Mick T. Rae W. Colin Duncan Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
description	Abstract Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone supplementation would increase fetal progesterone, affect progesterone target tissues in the developing fetal reproductive system and be metabolised to other bioactive steroids in the fetus. We investigated the effects of progesterone treatment during early pregnancy on maternal and fetal plasma progesterone concentrations, transcript abundance in the fetal pituitary and testes and circulating steroids, at day 75 gestation, using a clinically realistic ovine model. Endogenous progesterone concentrations were lower in male than female fetuses. Maternal progesterone administration increased male, but not female, fetal progesterone concentrations, also increasing circulating 11-dehydrocorticosterone in male fetuses. Maternal progesterone administration altered fetal pituitary and testicular function in ovine male fetuses. This suggests that there may be fetal sex specific effects of the use of progesterone in early pregnancy, and highlights that progesterone supplementation should be used only when there is clear evidence of efficacy and for as limited time as necessary.
format	article
author	Katarzyna J. Siemienowicz Yili Wang Magda Marečková Junko Nio-Kobayashi Paul A. Fowler Mick T. Rae W. Colin Duncan
author_facet	Katarzyna J. Siemienowicz Yili Wang Magda Marečková Junko Nio-Kobayashi Paul A. Fowler Mick T. Rae W. Colin Duncan
author_sort	Katarzyna J. Siemienowicz
title	Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
title_short	Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
title_full	Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
title_fullStr	Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
title_full_unstemmed	Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
title_sort	early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f3674f2be6cf4291a7eee02f7f0513c8
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Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses

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