Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective obse...
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2021
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oai:doaj.org-article:f3684c13d1224b80bc230ce58439ac3f2021-11-25T18:25:37ZLeaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection10.3390/microorganisms91123902076-2607https://doaj.org/article/f3684c13d1224b80bc230ce58439ac3f2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2390https://doaj.org/toc/2076-2607The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective observational study was conducted on patients with dengue who were categorized according to: (i) febrile versus critical phase and (ii) hospitalized patients with versus without the warning signs to evaluate the gut barrier using lactulose-to-mannitol excretion ratio (LEMR). Serum endotoxins, (1→3)-β-D-glucan (BG), and inflammatory parameters were measured. A total of 48 and 38 patients were enrolled in febrile illness and critical phase, respectively, while 22 and 64 patients presented with or without the warning signs, respectively. At enrollment, a positive LEMR test was found in 20 patients (91%) with warning signs, regardless of phase of infection. Likewise, serum endotoxins and BG, the indirect biomarkers for leaky gut, prominently increased in patients who developed severe dengue when compared with the non-severe dengue (endotoxins, 399.1 versus 143.4 pg/mL (<i>p</i> < 0.0001); BG, 123 versus 73.8 pg/mL (<i>p</i> = 0.016)). Modest impaired intestinal permeability occurred in dengue patients, particularly those with warning signs, and were associated with endotoxemia and elevated BG. Thus, leaky gut syndrome might be associated with severity of dengue infection.Wiwat ChancharoenthanaAsada LeelahavanichkulWassawon AriyanonSomratai VadcharavivadSuphasit PhatcharophaswattanakulSupitcha KamolratanakulPornsawan LeaungwutiwongWeerapong PhumratanaprapinPolrat WilairatanaMDPI AGarticleβ-D-glucandengueendotoxinslactulose-to-mannitol excretion ratioleaky gutintestinal permeabilityBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2390, p 2390 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
β-D-glucan dengue endotoxins lactulose-to-mannitol excretion ratio leaky gut intestinal permeability Biology (General) QH301-705.5 |
| spellingShingle |
β-D-glucan dengue endotoxins lactulose-to-mannitol excretion ratio leaky gut intestinal permeability Biology (General) QH301-705.5 Wiwat Chancharoenthana Asada Leelahavanichkul Wassawon Ariyanon Somratai Vadcharavivad Suphasit Phatcharophaswattanakul Supitcha Kamolratanakul Pornsawan Leaungwutiwong Weerapong Phumratanaprapin Polrat Wilairatana Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| description |
The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective observational study was conducted on patients with dengue who were categorized according to: (i) febrile versus critical phase and (ii) hospitalized patients with versus without the warning signs to evaluate the gut barrier using lactulose-to-mannitol excretion ratio (LEMR). Serum endotoxins, (1→3)-β-D-glucan (BG), and inflammatory parameters were measured. A total of 48 and 38 patients were enrolled in febrile illness and critical phase, respectively, while 22 and 64 patients presented with or without the warning signs, respectively. At enrollment, a positive LEMR test was found in 20 patients (91%) with warning signs, regardless of phase of infection. Likewise, serum endotoxins and BG, the indirect biomarkers for leaky gut, prominently increased in patients who developed severe dengue when compared with the non-severe dengue (endotoxins, 399.1 versus 143.4 pg/mL (<i>p</i> < 0.0001); BG, 123 versus 73.8 pg/mL (<i>p</i> = 0.016)). Modest impaired intestinal permeability occurred in dengue patients, particularly those with warning signs, and were associated with endotoxemia and elevated BG. Thus, leaky gut syndrome might be associated with severity of dengue infection. |
| format |
article |
| author |
Wiwat Chancharoenthana Asada Leelahavanichkul Wassawon Ariyanon Somratai Vadcharavivad Suphasit Phatcharophaswattanakul Supitcha Kamolratanakul Pornsawan Leaungwutiwong Weerapong Phumratanaprapin Polrat Wilairatana |
| author_facet |
Wiwat Chancharoenthana Asada Leelahavanichkul Wassawon Ariyanon Somratai Vadcharavivad Suphasit Phatcharophaswattanakul Supitcha Kamolratanakul Pornsawan Leaungwutiwong Weerapong Phumratanaprapin Polrat Wilairatana |
| author_sort |
Wiwat Chancharoenthana |
| title |
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| title_short |
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| title_full |
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| title_fullStr |
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| title_full_unstemmed |
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection |
| title_sort |
leaky gut syndrome is associated with endotoxemia and serum (1→3)-β-d-glucan in severe dengue infection |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/f3684c13d1224b80bc230ce58439ac3f |
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