Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers

Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Re...

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Autores principales: Galo Méndez-Matías, Cindy Velázquez-Velázquez, Rosario Castro-Oropeza, Alejandra Mantilla-Morales, Diana Ocampo-Sandoval, Ana Burgos-González, Carlos Heredia-Gutiérrez, Isabel Alvarado-Cabrero, Rosa Sánchez-Sandoval, Abigail Barco-Bazán, Fátima Chilaca-Rosas, Patricia Piña-Sánchez
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/f36d158ca80f4771bd54e89380da799f
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spelling oai:doaj.org-article:f36d158ca80f4771bd54e89380da799f2021-11-25T17:01:23ZPrevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers10.3390/cancers132256022072-6694https://doaj.org/article/f36d158ca80f4771bd54e89380da799f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5602https://doaj.org/toc/2072-6694Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico. Herein, we analyzed 414 Mexican patients with HNSCC, including oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC), and identified HPV DNA and p16 expression. Global gene expression profiles were analyzed in 25 HPV+/p16+ vs. HPV−/p16− cases. We found 32.3% p16+ and 22.3% HPV+ samples, HPV 16, 18, 39, 52, and 31 being the most frequent genotypes. For OPSCC, LASCC and OCSCC, 39.2, 14.7, and 9.6% were HPV+/p16+, respectively. High expression of SLIRP, KLF10, AREG, and LIMA was associated with poor survival; in contrast, high expression of MYB and SYCP2 correlated with better survival. In HPV+ cases, high expression of SLC25A39 and GJB2 was associated with poor survival. Likewise, EGFR, IL-1, IL-6, JAK-STAT, WNT, NOTCH, and ESR1 signaling pathways were downregulated in HPV+ cases. CSF1R, MYC, and SRC genes were identified as key hubs and therapeutic targets. Our study offers information regarding the molecular and clinical characteristics of HNSCC in Mexican patients.Galo Méndez-MatíasCindy Velázquez-VelázquezRosario Castro-OropezaAlejandra Mantilla-MoralesDiana Ocampo-SandovalAna Burgos-GonzálezCarlos Heredia-GutiérrezIsabel Alvarado-CabreroRosa Sánchez-SandovalAbigail Barco-BazánFátima Chilaca-RosasPatricia Piña-SánchezMDPI AGarticlehead and neck squamous cancerhuman papillomavirusMexicodifferential expressionbiomarkersprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5602, p 5602 (2021)
institution DOAJ
collection DOAJ
language EN
topic head and neck squamous cancer
human papillomavirus
Mexico
differential expression
biomarkers
prognosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle head and neck squamous cancer
human papillomavirus
Mexico
differential expression
biomarkers
prognosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Galo Méndez-Matías
Cindy Velázquez-Velázquez
Rosario Castro-Oropeza
Alejandra Mantilla-Morales
Diana Ocampo-Sandoval
Ana Burgos-González
Carlos Heredia-Gutiérrez
Isabel Alvarado-Cabrero
Rosa Sánchez-Sandoval
Abigail Barco-Bazán
Fátima Chilaca-Rosas
Patricia Piña-Sánchez
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
description Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico. Herein, we analyzed 414 Mexican patients with HNSCC, including oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC), and identified HPV DNA and p16 expression. Global gene expression profiles were analyzed in 25 HPV+/p16+ vs. HPV−/p16− cases. We found 32.3% p16+ and 22.3% HPV+ samples, HPV 16, 18, 39, 52, and 31 being the most frequent genotypes. For OPSCC, LASCC and OCSCC, 39.2, 14.7, and 9.6% were HPV+/p16+, respectively. High expression of SLIRP, KLF10, AREG, and LIMA was associated with poor survival; in contrast, high expression of MYB and SYCP2 correlated with better survival. In HPV+ cases, high expression of SLC25A39 and GJB2 was associated with poor survival. Likewise, EGFR, IL-1, IL-6, JAK-STAT, WNT, NOTCH, and ESR1 signaling pathways were downregulated in HPV+ cases. CSF1R, MYC, and SRC genes were identified as key hubs and therapeutic targets. Our study offers information regarding the molecular and clinical characteristics of HNSCC in Mexican patients.
format article
author Galo Méndez-Matías
Cindy Velázquez-Velázquez
Rosario Castro-Oropeza
Alejandra Mantilla-Morales
Diana Ocampo-Sandoval
Ana Burgos-González
Carlos Heredia-Gutiérrez
Isabel Alvarado-Cabrero
Rosa Sánchez-Sandoval
Abigail Barco-Bazán
Fátima Chilaca-Rosas
Patricia Piña-Sánchez
author_facet Galo Méndez-Matías
Cindy Velázquez-Velázquez
Rosario Castro-Oropeza
Alejandra Mantilla-Morales
Diana Ocampo-Sandoval
Ana Burgos-González
Carlos Heredia-Gutiérrez
Isabel Alvarado-Cabrero
Rosa Sánchez-Sandoval
Abigail Barco-Bazán
Fátima Chilaca-Rosas
Patricia Piña-Sánchez
author_sort Galo Méndez-Matías
title Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
title_short Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
title_full Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
title_fullStr Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
title_full_unstemmed Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
title_sort prevalence of hpv in mexican patients with head and neck squamous carcinoma and identification of potential prognostic biomarkers
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/f36d158ca80f4771bd54e89380da799f
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