Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers
Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Re...
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oai:doaj.org-article:f36d158ca80f4771bd54e89380da799f2021-11-25T17:01:23ZPrevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers10.3390/cancers132256022072-6694https://doaj.org/article/f36d158ca80f4771bd54e89380da799f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5602https://doaj.org/toc/2072-6694Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico. Herein, we analyzed 414 Mexican patients with HNSCC, including oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC), and identified HPV DNA and p16 expression. Global gene expression profiles were analyzed in 25 HPV+/p16+ vs. HPV−/p16− cases. We found 32.3% p16+ and 22.3% HPV+ samples, HPV 16, 18, 39, 52, and 31 being the most frequent genotypes. For OPSCC, LASCC and OCSCC, 39.2, 14.7, and 9.6% were HPV+/p16+, respectively. High expression of SLIRP, KLF10, AREG, and LIMA was associated with poor survival; in contrast, high expression of MYB and SYCP2 correlated with better survival. In HPV+ cases, high expression of SLC25A39 and GJB2 was associated with poor survival. Likewise, EGFR, IL-1, IL-6, JAK-STAT, WNT, NOTCH, and ESR1 signaling pathways were downregulated in HPV+ cases. CSF1R, MYC, and SRC genes were identified as key hubs and therapeutic targets. Our study offers information regarding the molecular and clinical characteristics of HNSCC in Mexican patients.Galo Méndez-MatíasCindy Velázquez-VelázquezRosario Castro-OropezaAlejandra Mantilla-MoralesDiana Ocampo-SandovalAna Burgos-GonzálezCarlos Heredia-GutiérrezIsabel Alvarado-CabreroRosa Sánchez-SandovalAbigail Barco-BazánFátima Chilaca-RosasPatricia Piña-SánchezMDPI AGarticlehead and neck squamous cancerhuman papillomavirusMexicodifferential expressionbiomarkersprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5602, p 5602 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
head and neck squamous cancer human papillomavirus Mexico differential expression biomarkers prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
head and neck squamous cancer human papillomavirus Mexico differential expression biomarkers prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Galo Méndez-Matías Cindy Velázquez-Velázquez Rosario Castro-Oropeza Alejandra Mantilla-Morales Diana Ocampo-Sandoval Ana Burgos-González Carlos Heredia-Gutiérrez Isabel Alvarado-Cabrero Rosa Sánchez-Sandoval Abigail Barco-Bazán Fátima Chilaca-Rosas Patricia Piña-Sánchez Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
description |
Head and neck squamous cell carcinomas (HNSCC) show a variety of biological and clinical characteristics that could depend on the association with the human papillomavirus (HPV). Biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico. Herein, we analyzed 414 Mexican patients with HNSCC, including oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC), and identified HPV DNA and p16 expression. Global gene expression profiles were analyzed in 25 HPV+/p16+ vs. HPV−/p16− cases. We found 32.3% p16+ and 22.3% HPV+ samples, HPV 16, 18, 39, 52, and 31 being the most frequent genotypes. For OPSCC, LASCC and OCSCC, 39.2, 14.7, and 9.6% were HPV+/p16+, respectively. High expression of SLIRP, KLF10, AREG, and LIMA was associated with poor survival; in contrast, high expression of MYB and SYCP2 correlated with better survival. In HPV+ cases, high expression of SLC25A39 and GJB2 was associated with poor survival. Likewise, EGFR, IL-1, IL-6, JAK-STAT, WNT, NOTCH, and ESR1 signaling pathways were downregulated in HPV+ cases. CSF1R, MYC, and SRC genes were identified as key hubs and therapeutic targets. Our study offers information regarding the molecular and clinical characteristics of HNSCC in Mexican patients. |
format |
article |
author |
Galo Méndez-Matías Cindy Velázquez-Velázquez Rosario Castro-Oropeza Alejandra Mantilla-Morales Diana Ocampo-Sandoval Ana Burgos-González Carlos Heredia-Gutiérrez Isabel Alvarado-Cabrero Rosa Sánchez-Sandoval Abigail Barco-Bazán Fátima Chilaca-Rosas Patricia Piña-Sánchez |
author_facet |
Galo Méndez-Matías Cindy Velázquez-Velázquez Rosario Castro-Oropeza Alejandra Mantilla-Morales Diana Ocampo-Sandoval Ana Burgos-González Carlos Heredia-Gutiérrez Isabel Alvarado-Cabrero Rosa Sánchez-Sandoval Abigail Barco-Bazán Fátima Chilaca-Rosas Patricia Piña-Sánchez |
author_sort |
Galo Méndez-Matías |
title |
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
title_short |
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
title_full |
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
title_fullStr |
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
title_full_unstemmed |
Prevalence of HPV in Mexican Patients with Head and Neck Squamous Carcinoma and Identification of Potential Prognostic Biomarkers |
title_sort |
prevalence of hpv in mexican patients with head and neck squamous carcinoma and identification of potential prognostic biomarkers |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/f36d158ca80f4771bd54e89380da799f |
work_keys_str_mv |
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