Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea

Abstract Recent data on non-B subtypes’ epidemiology among patients infected with human immunodeficiency virus-1 (HIV-1) in Korea are lacking. We aimed to assess the changing trends in the epidemiology of non-B subtypes of HIV-1 in Korea using phyloepidemiological analyses. We analyzed the demograph...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeong Eun Lee, Soon Ok Lee, Shinwon Lee, Sohee Park, Hyung-Hoi Kim, Kyung-Hwa Shin, Jin Suk Kang, Sun Hee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f36d7abc9b154f8daf969aea43e66229
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f36d7abc9b154f8daf969aea43e66229
record_format	dspace
spelling	oai:doaj.org-article:f36d7abc9b154f8daf969aea43e662292021-12-02T18:49:17ZEpidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea10.1038/s41598-021-94794-12045-2322https://doaj.org/article/f36d7abc9b154f8daf969aea43e662292021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94794-1https://doaj.org/toc/2045-2322Abstract Recent data on non-B subtypes’ epidemiology among patients infected with human immunodeficiency virus-1 (HIV-1) in Korea are lacking. We aimed to assess the changing trends in the epidemiology of non-B subtypes of HIV-1 in Korea using phyloepidemiological analyses. We analyzed the demographic records and sequencing data obtained from genotypic drug resistance tests between 2005 and 2019 from 517 patients infected with HIV attending a tertiary care hospital in Busan, Korea. Subtyping and phylogenetic analyses with reference sequences were performed. Additionally, transmission clusters were identified via maximum-likelihood trees. Non-B subtypes accounted for 21.3% of the 517 sequences. CRF01_AE (52.7%) was the most common non-B subtype, followed by CRF02_AG (16.4%), A1 (11.8%), and C (5.5%). The prevalence of non-B subtypes decreased from 36.4 to 13.4% by 2009, while it increased to 27.4% between 2015 and 2019. Among patients with non-B subtypes, the proportion of overseas sailors decreased from 66.7 to 7.5%; contrarily, the proportion of men-who-have-sex-with-men (MSM) increased from 0 to 46.9% over the study period. We identified 8 transmission clusters involving non-B subtypes, with sizes ranging from 2 to 4 patients, including 3 clusters containing MSM. Our results highlight the changes in the epidemiological trends of non-B subtypes of HIV-1 in Korea.Jeong Eun LeeSoon Ok LeeShinwon LeeSohee ParkHyung-Hoi KimKyung-Hwa ShinJin Suk KangSun Hee LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong Eun Lee Soon Ok Lee Shinwon Lee Sohee Park Hyung-Hoi Kim Kyung-Hwa Shin Jin Suk Kang Sun Hee Lee Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
description	Abstract Recent data on non-B subtypes’ epidemiology among patients infected with human immunodeficiency virus-1 (HIV-1) in Korea are lacking. We aimed to assess the changing trends in the epidemiology of non-B subtypes of HIV-1 in Korea using phyloepidemiological analyses. We analyzed the demographic records and sequencing data obtained from genotypic drug resistance tests between 2005 and 2019 from 517 patients infected with HIV attending a tertiary care hospital in Busan, Korea. Subtyping and phylogenetic analyses with reference sequences were performed. Additionally, transmission clusters were identified via maximum-likelihood trees. Non-B subtypes accounted for 21.3% of the 517 sequences. CRF01_AE (52.7%) was the most common non-B subtype, followed by CRF02_AG (16.4%), A1 (11.8%), and C (5.5%). The prevalence of non-B subtypes decreased from 36.4 to 13.4% by 2009, while it increased to 27.4% between 2015 and 2019. Among patients with non-B subtypes, the proportion of overseas sailors decreased from 66.7 to 7.5%; contrarily, the proportion of men-who-have-sex-with-men (MSM) increased from 0 to 46.9% over the study period. We identified 8 transmission clusters involving non-B subtypes, with sizes ranging from 2 to 4 patients, including 3 clusters containing MSM. Our results highlight the changes in the epidemiological trends of non-B subtypes of HIV-1 in Korea.
format	article
author	Jeong Eun Lee Soon Ok Lee Shinwon Lee Sohee Park Hyung-Hoi Kim Kyung-Hwa Shin Jin Suk Kang Sun Hee Lee
author_facet	Jeong Eun Lee Soon Ok Lee Shinwon Lee Sohee Park Hyung-Hoi Kim Kyung-Hwa Shin Jin Suk Kang Sun Hee Lee
author_sort	Jeong Eun Lee
title	Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
title_short	Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
title_full	Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
title_fullStr	Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
title_full_unstemmed	Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea
title_sort	epidemiological and phylogenetic analysis for non-b subtypes of human immunodeficiency virus type 1 in busan, korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f36d7abc9b154f8daf969aea43e66229
work_keys_str_mv	AT jeongeunlee epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT soonoklee epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT shinwonlee epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT soheepark epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT hyunghoikim epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT kyunghwashin epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT jinsukkang epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea AT sunheelee epidemiologicalandphylogeneticanalysisfornonbsubtypesofhumanimmunodeficiencyvirustype1inbusankorea
_version_	1718377599384682496

Epidemiological and phylogenetic analysis for non-B subtypes of human immunodeficiency virus type 1 in Busan, Korea

Ejemplares similares