Sarcopenia: assessment of disease burden and strategies to improve outcomes

Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II&rdq...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liguori I, Russo G, Aran L, Bulli G, Curcio F, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	sarcopenia elderly assessment therapy Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f372dd65cece4471bba91ba442d80e9d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f372dd65cece4471bba91ba442d80e9d
record_format	dspace
spelling	oai:doaj.org-article:f372dd65cece4471bba91ba442d80e9d2021-12-02T04:57:46ZSarcopenia: assessment of disease burden and strategies to improve outcomes1178-1998https://doaj.org/article/f372dd65cece4471bba91ba442d80e9d2018-05-01T00:00:00Zhttps://www.dovepress.com/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outc-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength – a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. According to the operational definition by the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function, which can be defined by low muscle strength or low physical performance. Moreover, biomarkers of sarcopenia have been identified for its early detection and for a detailed identification of the main pathophysiological mechanisms involved in its development. Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation. At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed. Keywords: sarcopenia, elderly, assessment, therapyLiguori IRusso GAran LBulli GCurcio FDella-Morte DGargiulo GTesta GCacciatore FBonaduce DAbete PDove Medical PressarticlesarcopeniaelderlyassessmenttherapyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 913-927 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia elderly assessment therapy Geriatrics RC952-954.6
spellingShingle	sarcopenia elderly assessment therapy Geriatrics RC952-954.6 Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P Sarcopenia: assessment of disease burden and strategies to improve outcomes
description	Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength – a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. According to the operational definition by the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function, which can be defined by low muscle strength or low physical performance. Moreover, biomarkers of sarcopenia have been identified for its early detection and for a detailed identification of the main pathophysiological mechanisms involved in its development. Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation. At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed. Keywords: sarcopenia, elderly, assessment, therapy
format	article
author	Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P
author_facet	Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P
author_sort	Liguori I
title	Sarcopenia: assessment of disease burden and strategies to improve outcomes
title_short	Sarcopenia: assessment of disease burden and strategies to improve outcomes
title_full	Sarcopenia: assessment of disease burden and strategies to improve outcomes
title_fullStr	Sarcopenia: assessment of disease burden and strategies to improve outcomes
title_full_unstemmed	Sarcopenia: assessment of disease burden and strategies to improve outcomes
title_sort	sarcopenia: assessment of disease burden and strategies to improve outcomes
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f372dd65cece4471bba91ba442d80e9d
work_keys_str_mv	AT liguorii sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT russog sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT aranl sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT bullig sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT curciof sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT dellamorted sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT gargiulog sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT testag sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT cacciatoref sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT bonaduced sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT abetep sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes
_version_	1718400985327468544

Sarcopenia: assessment of disease burden and strategies to improve outcomes

Ejemplares similares