Tear film osmolarity and dry eye disease: a review of the literature

Richard Potvin,1 Sarah Makari,1 Christopher J Rapuano21Science in Vision, Akron, NY, USA; 2Wills Eye Hospital, Philadelphia, PA, USAObjective: To evaluate the evidence in the peer-reviewed literature regarding the use of tear osmolarity as a physiological marker to diagnose, grade severity, and trac...

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Autores principales:	Potvin R, Makari S, Rapuano CJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f3742dfc711f46688dd6f405a1633730
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spelling	oai:doaj.org-article:f3742dfc711f46688dd6f405a16337302021-12-02T06:12:12ZTear film osmolarity and dry eye disease: a review of the literature1177-5483https://doaj.org/article/f3742dfc711f46688dd6f405a16337302015-11-01T00:00:00Zhttps://www.dovepress.com/tear-film-osmolarity-and-dry-eye-disease-a-review-of-the-literature-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Richard Potvin,1 Sarah Makari,1 Christopher J Rapuano21Science in Vision, Akron, NY, USA; 2Wills Eye Hospital, Philadelphia, PA, USAObjective: To evaluate the evidence in the peer-reviewed literature regarding the use of tear osmolarity as a physiological marker to diagnose, grade severity, and track therapeutic response in dry eye disease (DED). In addition, to review the evidence for the role of tear osmolarity in the pathophysiology of DED and ocular surface disease.Methods: A literature review of all publications after the year 2000, which included the keywords “tear osmolarity”, was conducted. Relevant articles were graded according to quality of evidence and research, using the University of Michigan Practice Guideline and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) rating systems. Articles were further categorized by the nature of any reported financial support and by the overall impression they provided related to tear osmolarity.Results: A total of 164 articles were identified as relevant to the search criteria, although some were editorials, and some were written in a foreign language. Of the total, it was possible to grade 159, and an overall impression was generated for 163. A positive impression of tear osmolarity in DED diagnosis was evident in 72% (117/163) of all articles, with a neutral impression in a further 21% (35/163); 7% had a negative impression. The percentage of positive impressions appeared independent of the quality of research; 73% (38/52) of articles graded high/moderate quality supported the use of tear film osmolarity measurement in DED diagnosis. Impressions were also independent of the source of financial support, with 72% (75/104) of independent studies positive.Conclusion: The literature broadly supports the use of tear film osmolarity as an objective numerical measure for diagnosing, grading severity, and managing treatment of DED.Keywords: TearLab, osmometer, keratoconjunctivitis sicca, dry eye diagnosisPotvin RMakari SRapuano CJDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 2039-2047 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Potvin R Makari S Rapuano CJ Tear film osmolarity and dry eye disease: a review of the literature
description	Richard Potvin,1 Sarah Makari,1 Christopher J Rapuano21Science in Vision, Akron, NY, USA; 2Wills Eye Hospital, Philadelphia, PA, USAObjective: To evaluate the evidence in the peer-reviewed literature regarding the use of tear osmolarity as a physiological marker to diagnose, grade severity, and track therapeutic response in dry eye disease (DED). In addition, to review the evidence for the role of tear osmolarity in the pathophysiology of DED and ocular surface disease.Methods: A literature review of all publications after the year 2000, which included the keywords “tear osmolarity”, was conducted. Relevant articles were graded according to quality of evidence and research, using the University of Michigan Practice Guideline and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) rating systems. Articles were further categorized by the nature of any reported financial support and by the overall impression they provided related to tear osmolarity.Results: A total of 164 articles were identified as relevant to the search criteria, although some were editorials, and some were written in a foreign language. Of the total, it was possible to grade 159, and an overall impression was generated for 163. A positive impression of tear osmolarity in DED diagnosis was evident in 72% (117/163) of all articles, with a neutral impression in a further 21% (35/163); 7% had a negative impression. The percentage of positive impressions appeared independent of the quality of research; 73% (38/52) of articles graded high/moderate quality supported the use of tear film osmolarity measurement in DED diagnosis. Impressions were also independent of the source of financial support, with 72% (75/104) of independent studies positive.Conclusion: The literature broadly supports the use of tear film osmolarity as an objective numerical measure for diagnosing, grading severity, and managing treatment of DED.Keywords: TearLab, osmometer, keratoconjunctivitis sicca, dry eye diagnosis
format	article
author	Potvin R Makari S Rapuano CJ
author_facet	Potvin R Makari S Rapuano CJ
author_sort	Potvin R
title	Tear film osmolarity and dry eye disease: a review of the literature
title_short	Tear film osmolarity and dry eye disease: a review of the literature
title_full	Tear film osmolarity and dry eye disease: a review of the literature
title_fullStr	Tear film osmolarity and dry eye disease: a review of the literature
title_full_unstemmed	Tear film osmolarity and dry eye disease: a review of the literature
title_sort	tear film osmolarity and dry eye disease: a review of the literature
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/f3742dfc711f46688dd6f405a1633730
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Tear film osmolarity and dry eye disease: a review of the literature

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