High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

Current optogenetic inhibition methods like light-controlled ion pumps require high-intensity light and disrupt physiological ion gradients. Here, the authors somatically target the anion-conducting opsin GtACR to eliminate spiking in distal axons and improve photocurrents, thus enhancing its utilit...

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Autores principales:	Mathias Mahn, Lihi Gibor, Pritish Patil, Katayun Cohen-Kashi Malina, Shir Oring, Yoav Printz, Rivka Levy, Ilan Lampl, Ofer Yizhar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f380d92112754a26873ab98e84a8428e
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spelling	oai:doaj.org-article:f380d92112754a26873ab98e84a8428e2021-12-02T17:31:31ZHigh-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins10.1038/s41467-018-06511-82041-1723https://doaj.org/article/f380d92112754a26873ab98e84a8428e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06511-8https://doaj.org/toc/2041-1723Current optogenetic inhibition methods like light-controlled ion pumps require high-intensity light and disrupt physiological ion gradients. Here, the authors somatically target the anion-conducting opsin GtACR to eliminate spiking in distal axons and improve photocurrents, thus enhancing its utility.Mathias MahnLihi GiborPritish PatilKatayun Cohen-Kashi MalinaShir OringYoav PrintzRivka LevyIlan LamplOfer YizharNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathias Mahn Lihi Gibor Pritish Patil Katayun Cohen-Kashi Malina Shir Oring Yoav Printz Rivka Levy Ilan Lampl Ofer Yizhar High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
description	Current optogenetic inhibition methods like light-controlled ion pumps require high-intensity light and disrupt physiological ion gradients. Here, the authors somatically target the anion-conducting opsin GtACR to eliminate spiking in distal axons and improve photocurrents, thus enhancing its utility.
format	article
author	Mathias Mahn Lihi Gibor Pritish Patil Katayun Cohen-Kashi Malina Shir Oring Yoav Printz Rivka Levy Ilan Lampl Ofer Yizhar
author_facet	Mathias Mahn Lihi Gibor Pritish Patil Katayun Cohen-Kashi Malina Shir Oring Yoav Printz Rivka Levy Ilan Lampl Ofer Yizhar
author_sort	Mathias Mahn
title	High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
title_short	High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
title_full	High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
title_fullStr	High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
title_full_unstemmed	High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
title_sort	high-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f380d92112754a26873ab98e84a8428e
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High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

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