High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

Current optogenetic inhibition methods like light-controlled ion pumps require high-intensity light and disrupt physiological ion gradients. Here, the authors somatically target the anion-conducting opsin GtACR to eliminate spiking in distal axons and improve photocurrents, thus enhancing its utilit...

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Autores principales: Mathias Mahn, Lihi Gibor, Pritish Patil, Katayun Cohen-Kashi Malina, Shir Oring, Yoav Printz, Rivka Levy, Ilan Lampl, Ofer Yizhar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/f380d92112754a26873ab98e84a8428e
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